Voigt R, Schröder S, Peiker G
Chemotherapy. 1985;31(6):417-24. doi: 10.1159/000238369.
In this paper pharmacokinetic data of acylureidopenicillins (azlocillin and piperacillin) in pregnant women in the last trimenon are compared with those from nonpregnant controls. Four g of each drug was administered as slow bolus injection intravenously. The concentrations in serum and urine of both drugs were determined by polarographic and microbiological methods, for comparison. We used for evaluation of pharmacokinetic data a computer program based on the equations of a two-compartment open pharmacokinetic model. Our investigations show that there are not any different pharmacokinetic values of both antibiotics between pregnant women and healthy nonpregnant volunteers. We can state that both antibiotics are well determined by both analyzing methods which give us identical pharmacokinetic results.
本文比较了孕晚期孕妇使用酰脲类青霉素（阿洛西林和哌拉西林）的药代动力学数据与非孕对照者的药代动力学数据。每种药物4克通过静脉缓慢推注给药。两种药物的血清和尿液浓度通过极谱法和微生物学方法测定，以便进行比较。我们使用基于二室开放药代动力学模型方程的计算机程序来评估药代动力学数据。我们的研究表明，孕妇和健康非孕志愿者之间这两种抗生素的药代动力学值没有任何差异。我们可以说，两种分析方法都能很好地测定这两种抗生素，且能得出相同的药代动力学结果。
