硝基咪唑衍生物GO 10213的抗菌活性
Antibacterial activity of GO 10213, a nitroimidazole derivative.
作者信息
Hof H, Ströder J
出版信息
Antimicrob Agents Chemother. 1986 May;29(5):953-4. doi: 10.1128/AAC.29.5.953.
Abstract
Compound GO 10213, a 5-nitroimidazole substituted at the 2 position, is more active against aerobic, microaerophilic, and anaerobic bacteria than metronidazole. The MICs for Salmonella typhimurium (2 to 128 micrograms/ml), Campylobacter spp. (0.06 to 16 micrograms/ml) and Bacteroides spp. (0.03 to 0.25 micrograms/ml) are definitely lower than those of metronidazole. Niridazole, a 5-nitrothiazole, is still more active.
摘要
化合物GO 10213是一种在2位被取代的5-硝基咪唑，它对需氧菌、微需氧菌和厌氧菌的活性比甲硝唑更强。鼠伤寒沙门氏菌（2至128微克/毫升）、弯曲杆菌属（0.06至16微克/毫升）和拟杆菌属（0.03至0.25微克/毫升）的最低抑菌浓度肯定低于甲硝唑。硝唑咪，一种5-硝基噻唑，活性更强。
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