Department of Biophysics, Bose Institute, Salt Lake, Kolkata 700 091, India.
Structural Biology and Bioinformatics Division, CSIR-IICB, 4 Raja S C Mullick Road, Kolkata 700 032, India.
Chem Commun (Camb). 2023 Jun 27;59(52):8095-8098. doi: 10.1039/d3cc01791e.
Our studies show Coomassie Brilliant Blue G-250 as a promising chemical chaperone that stabilises the α-helical native human insulin conformers, disrupting their aggregation. Furthermore, it also increases the insulin secretion. This multipolar effect coupled with its non-toxic nature could be useful for developing highly bioactive, targeted and biostable therapeutic insulin.
我们的研究表明考马斯亮蓝 G-250 是一种很有前途的化学伴侣，它可以稳定α-螺旋天然人胰岛素构象体，阻止其聚集。此外，它还能增加胰岛素的分泌。这种多极性效应与其非毒性性质相结合，可能有助于开发高生物活性、靶向和生物稳定的治疗性胰岛素。
