Sugimachi K, Matsufuji H, Kai H, Kitamura M, Maekawa S
Gan To Kagaku Ryoho. 1986 Apr;13(4 Pt 2):1360-5.
For clinical application in cases of carcinoma of the esophagus, we developed an endotract electrode ("applicator") for radiofrequency (RF) and an RF-generator (13.56 MHz) automatically controlled by a computer monitoring the temperature of the lesion. We then designed a combined therapy of hyperthermia, chemotherapy and radiotherapy (so-called hyperthermo-chemo-radiotherapy: HCR), on the basis of the additive or synergistic effects of hyperthermia combined with radiation and/or anticancer drugs. We applied this combined therapy to patients with esophageal carcinoma, using our newly developed heating system. HCR therapy was preoperatively performed on thirty-three patients with esophageal carcinoma. In the histopathological study of resected specimens, seven out of thirty-three patients (21.2%) showed markedly effective improvement, in seventeen (51.5%) the effects were moderately effective and in nine (27.3%) there were no apparent effects. The effectiveness (markedly + moderately effective/all cases) of preoperative HCR therapy was 72.7% (24/33), and significantly higher than the 50% (54/108) obtained in one hundred and eight patients who were preoperatively prescribed radiotherapy alone or in combination with chemotherapy. We then applied the combined therapy with hyperthermia to sixteen patients with unresectable esophageal carcinoma and eleven of these patients (68.8%) showed partial and moderate responses in esophagography. This combined therapy with hyperthermia is highly effective, and shows great promise for treating patients with esophageal carcinoma.
为了将其应用于食管癌的临床治疗，我们研发了一种用于射频（RF）的内插电极（“施药器”）以及一台由计算机自动控制的射频发生器（13.56兆赫），该计算机可监测病变部位的温度。基于热疗与放疗和/或抗癌药物的相加或协同作用，我们随后设计了一种热疗、化疗和放疗相结合的疗法（即所谓的热化疗放疗：HCR）。我们使用新研发的加热系统，将这种联合疗法应用于食管癌患者。对33例食管癌患者进行了术前HCR治疗。在对切除标本的组织病理学研究中，33例患者中有7例（21.2%）显示出明显有效的改善，17例（51.5%）效果中等有效，9例（27.3%）无明显效果。术前HCR治疗的有效率（明显有效+中等有效/所有病例）为72.7%（24/33），显著高于108例术前仅接受放疗或放化疗联合治疗患者的50%（54/108）。然后，我们将热疗联合疗法应用于16例无法切除的食管癌患者，其中11例（68.8%）在食管造影中显示出部分和中等程度的反应。这种热疗联合疗法非常有效，对食管癌患者的治疗显示出巨大的前景。
