Nishimura Y, Sakai K, Kitamura T, Hinata H, Yamashita H
Gan To Kagaku Ryoho. 1986 Apr;13(4 Pt 2):1492-8.
On a second mail survey (in 1984) concerning radiation-induced cancer following radiotherapy for benign diseases, 86 cases were collected from 95 hospitals in Japan. Adding these to 150 cases collected in the previous survey in 1979, 236 cases were accumulated. This is a report on the analysis of the 236 cases from a clinicopathological viewpoint. Underlying diseases consisted of cervical tuberculous lymphadenitis (125 cases), skin diseases (41 cases), benign thyroid diseases (19 cases), hemangioma (18 cases) and others (33 cases). Radiation-induced cancers, which were defined as cancers originating in the radiation field, including leukemia, consisted of hypopharyngeal cancer (68 cases), skin cancer (61 cases), laryngeal cancer (26 cases), esophageal cancer (23 cases), thyroid cancer (23 cases), salivary gland tumor (8 cases) and others (27 cases). Multiple primary cancers in the radiation field were observed in 7 cases. Average latent period was 28.9 years. It was demonstrated that the older the age at irradiation the shorter the latent period. Based on the population irradiated for benign diseases before 1977, which was collected in the first mail survey, incidence of radiation-induced cancers was estimated to be about 0.9%. The incidence varied with the period of radiotherapy; 1.9% for the period of radiotherapy before 1955, 0.4% for 1956-1965, 0.1% for 1966-1977. Although radiotherapy is now rarely indicated for benign diseases, it was shown in the first mail survey that more than 15,000 cases of benign diseases had been irradiated after 1956. It seems to be reasonable to consider that radiation-induced cancers after radiotherapy for benign diseases may continue to be discovered for several years in the future.
在1984年针对良性疾病放疗后辐射诱发癌症开展的第二次邮件调查中，从日本95家医院收集到86例病例。将这些病例与1979年首次调查收集的150例病例相加，共积累了236例病例。本文从临床病理角度对这236例病例进行分析报告。基础疾病包括颈部结核性淋巴结炎（125例）、皮肤病（41例）、良性甲状腺疾病（19例）、血管瘤（18例）及其他（33例）。辐射诱发癌症定义为起源于辐射野的癌症，包括白血病，有下咽癌（68例）、皮肤癌（61例）、喉癌（26例）、食管癌（23例）、甲状腺癌（23例）、涎腺肿瘤（8例）及其他（27例）。在辐射野观察到7例多原发性癌症。平均潜伏期为28.9年。结果表明，照射时年龄越大，潜伏期越短。根据首次邮件调查收集的1977年前因良性疾病接受照射的人群，估计辐射诱发癌症的发生率约为0.9%。发生率随放疗时期而异；1955年前放疗时期为1.9%，1956 - 1965年为0.4%，1966 - 1977年为0.1%。尽管现在很少对良性疾病进行放疗，但首次邮件调查显示，1956年后有超过15000例良性疾病接受了照射。似乎有理由认为，良性疾病放疗后辐射诱发癌症在未来几年可能会持续被发现。
