Uchida M
Gan No Rinsho. 1984 Sep;30(12 Suppl):1553-60.
In a review of 2710 patients with head and neck disease treated with irradiation at the Cancer Institute Hospital, Tokyo, between 1946 and 1955, second primary malignancies occurred in 35 of 2223 patients who were treated by reason of malignant tumors. The incidental rate of these second primary malignancies was significantly different from the population based rates. In 10 of 292 patients who were treated by irradiation for reason of benign disease such as cervical tuberculosis and hemangioma, primary cancers were developed under the long period of observation. These primary cancers were proved to be radiation-induced malignancies.
在对1946年至1955年间于东京癌症研究所医院接受放射治疗的2710例头颈疾病患者进行的回顾中，在因恶性肿瘤接受治疗的2223例患者中，有35例发生了第二原发性恶性肿瘤。这些第二原发性恶性肿瘤的发生率与基于人群的发生率有显著差异。在因宫颈结核和血管瘤等良性疾病接受放射治疗的292例患者中，有10例在长期观察中发生了原发性癌症。这些原发性癌症被证实是辐射诱发的恶性肿瘤。
