Böger Sophie, van Bergen Ilja, Beaudart Charlotte, Cheung Kei Long, Hiligsmann Mickaël
Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Department of Health Sciences, College of Health Medicine and Life Sciences, Brunel University London, London, UK.
Expert Rev Pharmacoecon Outcomes Res. 2023 Jul-Dec;23(8):921-931. doi: 10.1080/14737167.2023.2223983. Epub 2023 Jun 14.
To determine preferences for COVID-19 vaccinations in the young adult population in the United Kingdom (UK).
A discrete choice experiment survey was conducted in UK young adults. Participants were asked to choose between two hypothetical vaccines the one they preferred the most. Vaccines were defined by five attributes (effectiveness, risk of side effects, duration of protection, number of doses, confidence in available evidence), identified following a systematic literature review and qualitative interviews with 13 young adults. A random parameters logit model, a latent class model, and subgroup analyses were used to identify preferences.
One hundred and forty-nine respondents were included (70% women, mean age 23 years). All five attributes significantly influenced respondents' vaccination decisions. Respondents valued higher effectiveness, lower risk of side effects, longer protection duration, and a smaller number of doses. Based on the range of levels of each attribute, vaccine effectiveness was the most important attribute (relative importance 34%), followed by risk of side effects (32%), and duration of vaccine protection (22%).
The five investigated vaccine attributes appear to play an important role in young adults' decision-making process. Results of this study may help health authorities designing appropriate strategies in future vaccines campaigns in the younger UK population.
确定英国年轻成年人对新冠疫苗接种的偏好。
在英国年轻成年人中开展了一项离散选择实验调查。参与者被要求在两种假设的疫苗中选择他们最偏好的一种。疫苗由五个属性定义(有效性、副作用风险、保护持续时间、接种剂量数、对现有证据的信心),这些属性是在系统文献综述以及对13名年轻成年人进行定性访谈后确定的。采用随机参数logit模型、潜在类别模型和亚组分析来确定偏好。
纳入了149名受访者(70%为女性,平均年龄23岁)。所有五个属性均显著影响受访者的疫苗接种决策。受访者重视更高的有效性、更低的副作用风险、更长的保护持续时间以及更少的接种剂量。基于每个属性的水平范围,疫苗有效性是最重要的属性(相对重要性34%),其次是副作用风险(32%)和疫苗保护持续时间(22%)。
所调查的五个疫苗属性似乎在年轻成年人的决策过程中发挥重要作用。本研究结果可能有助于卫生当局为英国年轻人群体未来的疫苗接种活动制定适当策略。