Hinzpeter Eva-Lotta, Kairies-Schwarz Nadja, Beaudart Charlotte, Douxfils Jonathan, Nayak Dweeti, Hiligsmann Mickaël
Department of Health Services Research, Care and Public Health Research Institute (CAPHRI), Faculty of Health, Medicine and Life Sciences, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
Institute for Health Services Research and Health Economics, Centre for Health and Society, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Patient. 2025 Jul 10. doi: 10.1007/s40271-025-00753-7.
The COVID-19 pandemic has significantly influenced vaccination strategies and public health policies. Discrete choice experiments have emerged as a valuable tool for understanding preferences regarding vaccination. This study systematically reviews discrete choice experiments conducted on COVID-19 public vaccination preferences to identify key determinants influencing vaccine uptake and to assess methodological approaches used in these studies.
A systematic literature search was conducted across major databases, including PubMed, Scopus, and Web of Science, to identify discrete choice experiments focusing on COVID-19 vaccination preferences up to 31 December, 2024. Attribute categorization into five dimensions Outcome, Process, Cost, Trust, and Framing was performed and quality appraised according to the DIRECT checklist. Conditional relative importance as well as geographical differences were assessed.
The review identified 58 studies employing discrete choice experiments that assessed public COVID-19 vaccine preferences. Among attribute categories, outcome-related factors were the most frequently used and had the highest relative importance. Other commonly evaluated attributes included cost, origin/brand, and required doses. A notable geographic disparity was observed, with studies being unevenly distributed across different regions. Methodological heterogeneity was observed in attribute selection and experimental design.
This review emphasizes the importance of considering individual preferences into vaccination strategies to enhance uptake, particularly in preparation for future pandemics. The findings reveal that vaccine effectiveness and safety are key concerns for individuals. Future research could focus on increasing representation of underexamined regions in preference studies to better inform local policymakers in developing effective vaccination programs for future health crises.
This review was prospectively registered in PROSPERO (International Prospective Register of Systematic Reviews) with the ID CRD42025543234.
新冠疫情对疫苗接种策略和公共卫生政策产生了重大影响。离散选择实验已成为了解疫苗接种偏好的重要工具。本研究系统回顾了关于新冠公共疫苗接种偏好的离散选择实验，以确定影响疫苗接种率的关键决定因素，并评估这些研究中使用的方法。
在包括PubMed、Scopus和Web of Science在内的主要数据库中进行系统文献检索，以识别截至2024年12月31日关注新冠疫苗接种偏好的离散选择实验。将属性分为结果、过程、成本、信任和框架五个维度，并根据DIRECT清单进行质量评估。评估条件相对重要性以及地理差异。
该综述确定了58项采用离散选择实验评估公众新冠疫苗偏好的研究。在属性类别中，与结果相关的因素使用最为频繁，且相对重要性最高。其他常见评估属性包括成本、产地/品牌和所需剂量。观察到明显的地理差异，不同地区的研究分布不均。在属性选择和实验设计方面存在方法学异质性。
本综述强调在疫苗接种策略中考虑个人偏好以提高接种率的重要性，特别是为未来大流行做准备。研究结果表明，疫苗有效性和安全性是个人关注的关键问题。未来研究可侧重于增加偏好研究中未充分研究地区的代表性，以便更好地为地方政策制定者提供信息，制定针对未来健康危机的有效疫苗接种计划。
本综述已在PROSPERO（国际系统评价前瞻性注册库）中进行前瞻性注册，注册号为CRD42025543234。
