全身免疫炎症指数与腹主动脉钙化的相关性：一项全国性调查的结果。

Associations between systemic immune-inflammation index and abdominal aortic calcification: Results of a nationwide survey.

机构信息

Department of Hand & Microsurgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, 421002, China; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, Heidelberg, 69120, Germany; University of Heidelberg, Heidelberg, 69117, Germany.

Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

出版信息

Nutr Metab Cardiovasc Dis. 2023 Jul;33(7):1437-1443. doi: 10.1016/j.numecd.2023.04.015. Epub 2023 Apr 22.

DOI:10.1016/j.numecd.2023.04.015

PMID:37156667

Abstract

BACKGROUND AND AIM

The Systemic Immune-Inflammation Index (SII) is a novel index of inflammation assessment that appears to be superior to the common single blood index in the assessment of cardiovascular disease. The purpose of this study was to investigate the association between SII and abdominal aortic calcification (AAC) in adults.

METHODS AND RESULTS

Multivariate logistic regression, sensitivity analysis, and smoothing curve fitting were used to investigate the relationship between SII and AAC based on data from the National Health and Nutrition Examination Survey (NHANES) 2013-2014. Subgroup analysis and interaction tests were used to investigate whether this association was stable across populations. There was a positive association between SII and ACC in 3036 participants >40 years of age. In the fully adjusted model, each 100-unit increase in SII was associated with a 4% increase in the risk of developing severe AAC [1.04 (1.02, 1.07)]. Participants in the highest quartile of SII had a 47% higher risk of developing severe AAC than those in the lowest quartile [1.47 (1.10, 1.99)]. This positive association was more pronounced in older adults >60 years of age.

CONCLUSIONS

SII is positively associated with AAC in US adults. Our findings imply that SII has the potential to improve AAC prevention in the general population.

摘要

背景与目的

全身性免疫炎症指数（SII）是一种新的炎症评估指标，在评估心血管疾病方面，它似乎优于常见的单一血液指标。本研究旨在探讨 SII 与成年人腹主动脉钙化（AAC）之间的关系。

方法和结果

基于 2013-2014 年全国健康和营养调查（NHANES）的数据，采用多变量逻辑回归、敏感性分析和平滑曲线拟合来研究 SII 与 AAC 之间的关系。采用亚组分析和交互检验来检验这种关联在人群中的稳定性。在 3036 名年龄>40 岁的参与者中，SII 与 ACC 之间存在正相关关系。在完全调整的模型中，SII 每增加 100 个单位，发生严重 AAC 的风险增加 4%[1.04（1.02，1.07)]。SII 最高四分位数的参与者发生严重 AAC 的风险比最低四分位数的参与者高 47%[1.47（1.10，1.99)]。这种正相关关系在年龄>60 岁的老年人中更为明显。