Carney J A, Headington J T, Su W P
Arch Dermatol. 1986 Jul;122(7):790-8. doi: 10.1001/archderm.122.7.790.
Cutaneous myxoma(s) occurred in 22 (54%) of 41 patients with the complex of myxomas, spotty pigmentation, and endocrine overactivity. Of the 16 patients who had cardiac myxoma(s), the cutaneous tumor(s) was (were) detected in 13 (81%) of them prior to diagnosis of the cardiac neoplasm. Thus, the cutaneous tumor may herald a potentially fatal cardiac neoplasm (and other important conditions as well). Clinical features of the lesion were as follows: early appearance (mean age, 18 years); multicentricity (71% of patients); small size (usually less than 1 cm in diameter); widespread distribution but with predilection for certain sites (eyelids, ears, nipples); and tendency for recurrence. Pathologic features included the following: location in dermis, subcutis, or both; sharp circumscription (sometimes encapsulation); hypocellularity; abundant myxoid stroma; prominent capillaries; lobulation (larger lesions); and occasional presence of an epithelial component.
在41例患有黏液瘤、散在色素沉着和内分泌功能亢进综合征的患者中，有22例（54%）发生了皮肤黏液瘤。在16例患有心脏黏液瘤的患者中，13例（81%）在心脏肿瘤诊断之前就检测到了皮肤肿瘤。因此，皮肤肿瘤可能预示着潜在致命的心脏肿瘤（以及其他重要疾病）。该病变的临床特征如下：出现较早（平均年龄18岁）；多中心性（71%的患者）；体积小（直径通常小于1厘米）；分布广泛，但某些部位更易发生（眼睑、耳朵、乳头）；且有复发倾向。病理特征包括：位于真皮、皮下组织或两者皆有；边界清晰（有时有包膜）；细胞稀少；大量黏液样基质；明显的毛细血管；分叶状（较大病变）；偶尔有上皮成分。
