El-Husseiny Ahmed A, Abdelmaksoud Nourhan M, Mageed Sherif S Abdel, Salman Aya, Zaki Mohamed Bakr, El-Mahdy Hesham A, Ismail Ahmed, Abd-Elmawla Mai A, El-Husseiny Hussein M, Abulsoud Ahmed I, Elshaer Shereen Saeid, Elsakka Elsayed G E, Fathi Doaa, El-Dakroury Walaa A, Doghish Ahmed S
Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt; Department of Biochemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City 11829, Cairo, Egypt.
Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
Pathol Res Pract. 2023 Aug;248:154590. doi: 10.1016/j.prp.2023.154590. Epub 2023 Jun 7.
Cancer of the salivary glands is one of the five major types of head and neck cancer. Due to radioresistance and a strong propensity for metastasis, the survival rate for nonresectable malignant tumors is dismal. Hence, more research is needed on salivary cancer's pathophysiology, particularly at the molecular level. The microRNAs (miRNAs) are a type of noncoding RNA that controls as many as 30% of all genes that code for proteins at the posttranscriptional level. Signature miRNA expression profiles have been established in several cancer types, suggesting a role for miRNAs in the incidence and progression of human malignancies. Salivary cancer tissues were shown to have significantly aberrant levels of miRNAs compared to normal salivary gland tissues, supporting the hypothesis that miRNAs play a crucial role in the carcinogenesis of salivary gland cancer (SGC). Besides, several SGC research articles reported potential biomarkers and therapeutic targets for the miRNA-based treatment of this malignancy. In this review, we will explore the regulatory impact of miRNAs on the processes underlying the molecular pathology of SGC and provide an up-to-date summary of the literature on miRNAs that impacted this malignancy. We will eventually share information about their possible use as diagnostic, prognostic, and therapeutic biomarkers in SGC.
唾液腺癌是头颈部五大主要癌症类型之一。由于其具有放射抗性且极易发生转移，不可切除的恶性肿瘤的存活率很低。因此，需要对唾液癌的病理生理学，尤其是分子水平的病理生理学进行更多研究。微小RNA（miRNA）是一类非编码RNA，在转录后水平上控制多达30%的蛋白质编码基因。在几种癌症类型中已经建立了特征性的miRNA表达谱，这表明miRNA在人类恶性肿瘤的发生和发展中发挥作用。与正常唾液腺组织相比，唾液癌组织中miRNA的水平显著异常，这支持了miRNA在唾液腺癌（SGC）致癌过程中起关键作用的假说。此外，几篇关于SGC的研究文章报道了基于miRNA治疗这种恶性肿瘤的潜在生物标志物和治疗靶点。在这篇综述中，我们将探讨miRNA对SGC分子病理学基础过程的调节作用，并提供有关影响这种恶性肿瘤的miRNA文献的最新总结。我们最终将分享它们在SGC中作为诊断、预后和治疗生物标志物的可能用途的信息。
