Deparment of Physiology, Rashid Latif Medical College, Lahore, Punjab, 54700, Pakistan.
KAM School of Life Sciences, Forman Christian College (a Chartered University) Lahore, Punjab, Pakistan.
Environ Res. 2023 Sep 1;232:116290. doi: 10.1016/j.envres.2023.116290. Epub 2023 Jun 7.
With recent advancements in nanomedicines and their associated research with biological fields, their translation into clinically-applicable products is still below promises. Quantum dots (QDs) have received immense research attention and investment in the four decades since their discovery. We explored the extensive biomedical applications of QDs, viz. Bio-imaging, drug research, drug delivery, immune assays, biosensors, gene therapy, diagnostics, their toxic effects, and bio-compatibility. We unravelled the possibility of using emerging data-driven methodologies (bigdata, artificial intelligence, machine learning, high-throughput experimentation, computational automation) as excellent sources for time, space, and complexity optimization. We also discussed ongoing clinical trials, related challenges, and the technical aspects that should be considered to improve the clinical fate of QDs and promising future research directions.
随着纳米医学的最新进展及其与生物领域的相关研究，其向临床应用产品的转化仍不尽如人意。自发现以来，量子点 (QD) 在过去四十年中受到了广泛的研究关注和投资。我们探讨了 QD 在生物医学中的广泛应用，即生物成像、药物研究、药物递送、免疫分析、生物传感器、基因治疗、诊断、其毒性作用和生物相容性。我们揭示了使用新兴的数据驱动方法（大数据、人工智能、机器学习、高通量实验、计算自动化）作为时间、空间和复杂性优化的极好来源的可能性。我们还讨论了正在进行的临床试验、相关挑战以及应考虑改进 QD 的临床命运和有前途的未来研究方向的技术方面。
