Golding D N
Ann Rheum Dis. 1986 Jun;45(6):523-5. doi: 10.1136/ard.45.6.523.
An 18 year old girl concurrently developed skin lesions of morphoea (localised scleroderma) and pain and swelling of the hands and fingers. There were no dermatological or systemic signs of systemic sclerosis. The immunological features (high titred speckled antinuclear antibody, negative DNA binding, high titred positive anti-RNP and negative anti-Sm antibodies, speckled nuclear Ig fluorescence in the epidermis of the skin lesions) were consistent with mixed connective tissue disease, and it is suggested that the morphoea represented a component of this condition.
一名18岁女孩同时出现硬斑病（局限性硬皮病）的皮肤损害以及手部和手指的疼痛与肿胀。无系统性硬化症的皮肤或全身表现。免疫特征（高滴度斑点型抗核抗体、DNA结合阴性、高滴度抗RNP阳性及抗Sm抗体阴性、皮肤损害表皮中斑点状核Ig荧光）符合混合性结缔组织病，提示硬斑病为此病的一个组成部分。
