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一种基于时频图像和深度学习方法的新型混合方法用于偏头痛疾病诊断及刺激效应研究。

A New Hybrid Approach Based on Time Frequency Images and Deep Learning Methods for Diagnosis of Migraine Disease and Investigation of Stimulus Effect.

作者信息

Orhanbulucu Fırat, Latifoğlu Fatma, Baydemir Recep

机构信息

Department of Biomedical Engineering, Inonu University, Battalgazi 44000, Turkey.

Department of Biomedical Engineering, Erciyes University, Kayseri 38039, Turkey.

出版信息

Diagnostics (Basel). 2023 May 28;13(11):1887. doi: 10.3390/diagnostics13111887.


DOI:10.3390/diagnostics13111887
PMID:37296739
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10253200/
Abstract

Migraine is a neurological disorder that is associated with severe headaches and seriously affects the lives of patients. Diagnosing Migraine Disease (MD) can be laborious and time-consuming for specialists. For this reason, systems that can assist specialists in the early diagnosis of MD are important. Although migraine is one of the most common neurological diseases, there are very few studies on the diagnosis of MD, especially electroencephalogram (EEG)-and deep learning (DL)-based studies. For this reason, in this study, a new system has been proposed for the early diagnosis of EEG- and DL-based MD. In the proposed study, EEG signals obtained from the resting state (R), visual stimulus (V), and auditory stimulus (A) from 18 migraine patients and 21 healthy control (HC) groups were used. By applying continuous wavelet transform (CWT) and short-time Fourier transform (STFT) methods to these EEG signals, scalogram-spectrogram images were obtained in the time-frequency (T-F) plane. Then, these images were applied as inputs in three different convolutional neural networks (CNN) architectures (AlexNet, ResNet50, SqueezeNet) that proposed deep convolutional neural network (DCNN) models and classification was performed. The results of the classification process were evaluated, taking into account accuracy (acc.), sensitivity (sens.), specificity (spec.), and performance criteria, and the performances of the preferred methods and models in this study were compared. In this way, the situation, method, and model that showed the most successful performance for the early diagnosis of MD were determined. Although the classification results are close to each other, the resting state, CWT method, and AlexNet classifier showed the most successful performance (Acc: 99.74%, Sens: 99.9%, Spec: 99.52%). We think that the results obtained in this study are promising for the early diagnosis of MD and can be of help to experts.

摘要

偏头痛是一种与严重头痛相关的神经系统疾病,严重影响患者的生活。对于专家来说,诊断偏头痛疾病(MD)可能既费力又耗时。因此,能够协助专家进行MD早期诊断的系统非常重要。尽管偏头痛是最常见的神经系统疾病之一,但关于MD诊断的研究却很少,尤其是基于脑电图(EEG)和深度学习(DL)的研究。因此,在本研究中,提出了一种基于EEG和DL的MD早期诊断新系统。在所提出的研究中,使用了从18名偏头痛患者和21名健康对照(HC)组的静息状态(R)、视觉刺激(V)和听觉刺激(A)中获得的EEG信号。通过将连续小波变换(CWT)和短时傅里叶变换(STFT)方法应用于这些EEG信号,在时频(T-F)平面上获得了尺度图-频谱图图像。然后,将这些图像作为输入应用于三种不同的卷积神经网络(CNN)架构(AlexNet、ResNet50、SqueezeNet),这些架构提出了深度卷积神经网络(DCNN)模型并进行了分类。考虑到准确率(acc.)、灵敏度(sens.)、特异性(spec.)和性能标准,对分类过程的结果进行了评估,并比较了本研究中首选方法和模型的性能。通过这种方式,确定了在MD早期诊断中表现出最成功性能的情况、方法和模型。尽管分类结果彼此接近,但静息状态、CWT方法和AlexNet分类器表现出最成功的性能(Acc:99.74%,Sens:99.9%,Spec:99.52%)。我们认为本研究中获得的结果对于MD的早期诊断很有前景,并且对专家可能会有所帮助。

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本文引用的文献

[1]
Application of EEG in migraine.

Front Hum Neurosci. 2023-2-17

[2]
Supervised Machine Learning and Deep Learning Techniques for Epileptic Seizure Recognition Using EEG Signals-A Systematic Literature Review.

Bioengineering (Basel). 2022-12-8

[3]
Bibliometric Analysis of Quantitative Electroencephalogram Research in Neuropsychiatric Disorders From 2000 to 2021.

Front Psychiatry. 2022-5-23

[4]
Neurogenic Inflammation: The Participant in Migraine and Recent Advancements in Translational Research.

Biomedicines. 2021-12-30

[5]
A deep learning approach in automated detection of schizophrenia using scalogram images of EEG signals.

Phys Eng Sci Med. 2022-3

[6]
Migraine detection from EEG signals using tunable Q-factor wavelet transform and ensemble learning techniques.

Phys Eng Sci Med. 2021-12

[7]
Abnormalities in cortical pattern of coherence in migraine detected using ultra high-density EEG.

Brain Commun. 2021-4-2

[8]
Deep learning for brain disorders: from data processing to disease treatment.

Brief Bioinform. 2021-3-22

[9]
Diagnose ADHD disorder in children using convolutional neural network based on continuous mental task EEG.

Comput Methods Programs Biomed. 2020-12

[10]
Prevalence and Diagnosis of Neurological Disorders Using Different Deep Learning Techniques: A Meta-Analysis.

J Med Syst. 2020-1-4

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