Lee Benjamin E, Altorki Nasser
Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Suite M404, Weill Cornell Medicine of Cornell University, 525 East 68th Street, New York, NY 10065, USA.
Cancers (Basel). 2023 May 25;15(11):2914. doi: 10.3390/cancers15112914.
The Lung Cancer Study Group previously established lobectomy as the standard of care for treatment of clinical T1N0 NSCLC. Advances in imaging technology and refinements in staging have prompted a re-investigation to determine the non-inferiority of sub-lobar resections to lobectomies. Two recent randomized studies, JCOG 0802 and CALGB 140503, are reviewed here in the context of LCSG 0821. The studies confirm non-inferiority for sub-lobar resection (wedge or segmentectomy) compared to lobectomy for peripheral T1N0 NSCLC less than or equal to 2 cm. Sub-lobar resection should therefore be considered the new standard of care in this sub-set of patients with NSCLC.
肺癌研究组先前已将肺叶切除术确立为临床T1N0非小细胞肺癌治疗的护理标准。成像技术的进步和分期的细化促使人们重新进行调查，以确定肺叶以下切除术相对于肺叶切除术的非劣效性。本文在LCSG 0821的背景下对两项近期的随机研究JCOG 0802和CALGB 140503进行了综述。这些研究证实，对于直径小于或等于2 cm的外周T1N0非小细胞肺癌，肺叶以下切除术（楔形切除术或肺段切除术）相对于肺叶切除术具有非劣效性。因此，对于这一非小细胞肺癌患者亚组，肺叶以下切除术应被视为新的护理标准。
