Mendez M F, Cummings J L, Benson D F
Arch Neurol. 1986 Aug;43(8):766-70. doi: 10.1001/archneur.1986.00520080014012.
Depression is common in epileptics, but few studies of this relationship exist. We investigated the prevalence of depression in comparably disabled outpatients and its phenomenology in psychiatrically hospitalized inpatients. Fifty-five percent of 175 outpatient epileptics and 30% of 70 matched controls reported depression; 30% of epileptics vs 7% of controls reported prior suicide attempts. Epileptics were four times more likely to have been hospitalized for depression than nonepileptics. Twenty depressed epileptic inpatients were characterized by "endogenous" rather than "neurotic" features with more psychotic traits, paranoia, and underlying chronic dysthymia. Sixteen patients had complex partial seizures, and ten of 11 patients had a lateralized electroencephalographic focus lateralized to the left hemisphere. These results suggest a specific epileptic psychosyndrome due to limbic dysfunction.
抑郁症在癫痫患者中很常见，但关于这种关系的研究很少。我们调查了残疾程度相当的门诊患者中抑郁症的患病率及其在精神科住院患者中的现象学特征。175名门诊癫痫患者中有55%报告有抑郁症，70名匹配的对照组中有30%报告有抑郁症；癫痫患者中有30%报告曾有自杀未遂，而对照组中这一比例为7%。癫痫患者因抑郁症住院的可能性是非癫痫患者的四倍。20名抑郁的癫痫住院患者的特征为具有更多精神病性特征、偏执和潜在慢性心境恶劣的“内源性”而非“神经症性”特征。16名患者有复杂部分性发作，11名患者中有10名脑电图局灶性异常定位于左半球。这些结果提示存在一种由边缘系统功能障碍导致的特定癫痫性精神综合征。
