Yo Yoshie, Kawasaki Kaoru, Moriuchi Kaori, Shiro Reona, Shimaoka Masao, Matsumura Noriomi
Department of Obstetrics and Gynecology, Faculty of Medicine, Kindai University, 377-2 Ohnohigashi, Osaka-Sayama 589-8511, Osaka, Japan.
Department of Obstetrics and Gynecology, Saiseikai Tondabayashi Hospital, 1-3-36 Koyodai, Tondabayashi 584-0082, Osaka, Japan.
Healthcare (Basel). 2023 Jun 5;11(11):1657. doi: 10.3390/healthcare11111657.
Several studies in Europe and the United States have shown that sexual intercourse (SI) during pregnancy is not associated with preterm birth. However, it is unclear whether these findings apply to pregnant Japanese women. The aim of this prospective cohort study was to elucidate the influence of SI during pregnancy on preterm birth in Japan. A total of 182 women who underwent antenatal care and delivery were included in this study. The frequency of SI was assessed using a questionnaire, and its association with preterm birth was analyzed. The results showed that SI during pregnancy was associated with a significantly higher cumulative preterm birth rate ( = 0.018), which was more pronounced for SI more than once a week ( < 0.0001). Multivariate analysis showed that SI, bacterial vaginosis in the second trimester, previous preterm birth, and smoking during pregnancy were independent risk factors for preterm birth. The combination of SI and second trimester bacterial vaginosis was associated with a 60% preterm birth rate, whereas either factor alone was associated with a lower rate, suggesting a synergistic effect ( < 0.0001). Future studies are needed to investigate the effect of prohibiting SI in pregnant women with bacterial vaginosis on preterm birth.
欧洲和美国的多项研究表明，孕期性交（SI）与早产无关。然而，这些研究结果是否适用于日本孕妇尚不清楚。这项前瞻性队列研究的目的是阐明孕期性交对日本早产的影响。本研究共纳入了182名接受产前护理和分娩的女性。通过问卷调查评估性交频率，并分析其与早产的关联。结果显示，孕期性交与累积早产率显著升高相关（=0.018），每周性交超过一次的情况更为明显（<0.0001）。多因素分析表明，性交、孕中期细菌性阴道病、既往早产和孕期吸烟是早产的独立危险因素。性交与孕中期细菌性阴道病共同存在时，早产率为60%，而单独任何一个因素导致的早产率较低，提示存在协同效应（<0.0001）。未来需要开展研究，调查禁止细菌性阴道病孕妇性交对早产的影响。
