Awatade Nikhil T, Wark Peter A B, Chan Andrew S L, Mamun S M Abdullah Al, Mohd Esa Nurul Yaqeen, Matsunaga Kazuto, Rhee Chin Kook, Hansbro Philip M, Sohal Sukhwinder Singh
Immune Health Program, Hunter Medical Research Institute and University of Newcastle, Newcastle 2305, Australia.
Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle 2305, Australia.
J Clin Med. 2023 May 31;12(11):3791. doi: 10.3390/jcm12113791.
Chronic obstructive pulmonary disease (COPD) is significant cause of morbidity and mortality worldwide. There is mounting evidence suggesting that COPD patients are at increased risk of severe COVID-19 outcomes; however, it remains unclear whether they are more susceptible to acquiring SARS-CoV-2 infection. In this comprehensive review, we aim to provide an up-to-date perspective of the intricate relationship between COPD and COVID-19. We conducted a thorough review of the literature to examine the evidence regarding the susceptibility of COPD patients to COVID-19 infection and the severity of their disease outcomes. While most studies have found that pre-existing COPD is associated with worse COVID-19 outcomes, some have yielded conflicting results. We also discuss confounding factors such as cigarette smoking, inhaled corticosteroids, and socioeconomic and genetic factors that may influence this association. Furthermore, we review acute COVID-19 management, treatment, rehabilitation, and recovery in COPD patients and how public health measures impact their care. In conclusion, while the association between COPD and COVID-19 is complex and requires further investigation, this review highlights the need for careful management of COPD patients during the pandemic to minimize the risk of severe COVID-19 outcomes.
慢性阻塞性肺疾病（COPD）是全球发病和死亡的重要原因。越来越多的证据表明，COPD患者出现严重COVID-19结局的风险增加；然而，他们是否更容易感染SARS-CoV-2仍不清楚。在这篇综述中，我们旨在提供关于COPD与COVID-19之间复杂关系的最新观点。我们对文献进行了全面回顾，以研究有关COPD患者对COVID-19感染的易感性及其疾病结局严重程度的证据。虽然大多数研究发现，既往存在的COPD与更差的COVID-19结局相关，但也有一些研究得出了相互矛盾的结果。我们还讨论了可能影响这种关联的混杂因素，如吸烟、吸入性糖皮质激素以及社会经济和遗传因素。此外，我们回顾了COPD患者急性COVID-19的管理、治疗、康复和恢复情况，以及公共卫生措施如何影响他们的护理。总之，虽然COPD与COVID-19之间的关联很复杂，需要进一步研究，但本综述强调了在大流行期间对COPD患者进行谨慎管理的必要性，以将严重COVID-19结局的风险降至最低。
