La Torre Giuseppe, Paglione Gianluca, Barone Lavinia Camilla, Cammalleri Vittoria, Faticoni Augusto, Marte Mattia, Pocino Roberta Noemi, Previte Carlo Maria, Bongiovanni Andrea, Colaprico Corrado, Ricci Eleonora, Imeshtari Valentin, Manai Maria Vittoria, Shaholli David, Barletta Vanessa India, Carluccio Giovanna, Moretti Luca, Vezza Francesca, Volpicelli Lorenzo, Massetti Anna Paola, Cinti Lilia, Roberto Piergiorgio, Napoli Anna, Antonelli Guido, Mastroianni Claudio Maria, Sernia Sabina
Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.
J Clin Med. 2023 Jun 5;12(11):3861. doi: 10.3390/jcm12113861.
The risk of reinfection with SARS-CoV-2 has been rapidly increased with the circulation of concerns about variants. So, the aim of our study was to evaluate the factors that increase the risk of this reinfection in healthcare workers compared to those who have never been positive and those who have had only one positivity.
A case-control study was carried out at the Teaching Hospital Policlinico Umberto I in Rome, Sapienza University of Rome, in the period between 6 March 2020 and 3 June 2022. Cases are healthcare workers who have developed a reinfection with the SARS-CoV-2 virus, while controls were either healthcare workers who tested positive once or those who have never tested positive for SARS-CoV-2.
134 cases and 267 controls were recruited. Female gender is associated with a higher odds of developing reinfection (OR: 2.42; 95% CI: 1.38-4.25). Moreover, moderate or high alcohol consumption is associated with higher odds of reinfection (OR: 1.49; 95% CI: 1.19-1.87). Diabetes is also associated with higher odds of reinfection (OR: 3.45; 95% CI: 1.41-8.46). Finally, subjects with increased red blood cell counts have higher odds of reinfection (OR: 1.69; 95% CI: 1.21-2.25).
From the prevention point of view, these findings indicate that particular attention should be paid to subjects with diabetes mellitus, women and alcoholic drinkers. These results could also suggest that contact tracing represents a fundamental approach model against the SARS-CoV-2 pandemic, together with the health information of participants.
随着对新冠病毒变异株的关注传播，再次感染新冠病毒的风险迅速增加。因此，我们研究的目的是评估与从未感染过新冠病毒以及仅感染过一次新冠病毒的医护人员相比，增加再次感染风险的因素。
2020年3月6日至2022年6月3日期间，在罗马的罗马第一大学综合医院进行了一项病例对照研究。病例为再次感染新冠病毒的医护人员，而对照为曾检测呈阳性一次的医护人员或从未检测出新冠病毒呈阳性的医护人员。
招募了134例病例和267名对照。女性与再次感染的较高几率相关（比值比：2.42；95%置信区间：1.38 - 4.25）。此外，中度或大量饮酒与再次感染的较高几率相关（比值比：1.49；95%置信区间：1.19 - 1.87）。糖尿病也与再次感染的较高几率相关（比值比：3.45；95%置信区间：1.41 - 8.46）。最后，红细胞计数增加的受试者再次感染的几率更高（比值比：1.69；95%置信区间：1.21 - 2.25）。
从预防的角度来看，这些发现表明应特别关注糖尿病患者、女性和饮酒者。这些结果还可能表明，接触者追踪与参与者的健康信息一起，是对抗新冠疫情的一种基本方法模式。
