Kennedy T J, Pistone G, Miller S H
Plast Reconstr Surg. 1979 Jan;63(1):101-10. doi: 10.1097/00006534-197901000-00016.
A model flap was developed in the rat which allowed us to quantitate microcirculatory blood flow within a flap, and to correlate the flow with the length of flap eventually surviving. A critical flow of 0.02 and 0.03 ml/min/gm (measured during the first 24 hours after flap elevation by radioactive microspheres) appears to be necessary for tissue survival. Reserpine, in a dose of 5 mg/kg, did not increase blood flow in the flap or the length of flap surviving in this model.
我们在大鼠身上构建了一个模型皮瓣，这使我们能够定量皮瓣内的微循环血流量，并将血流量与最终存活的皮瓣长度关联起来。组织存活似乎需要0.02和0.03毫升/分钟/克的临界血流量（在皮瓣掀起后的头24小时内通过放射性微球测量）。在该模型中，5毫克/千克剂量的利血平并未增加皮瓣的血流量或存活皮瓣的长度。
