Kerrigan C L, Daniel R K
Plast Reconstr Surg. 1982 Nov;70(5):541-9. doi: 10.1097/00006534-198211000-00001.
Pigs with random skin flaps were treated with phenoxybenzamine, isoxsuprine, or reserpine. No significant increase in flap survival was detected. In selected animals, cutaneous blood flow was measured using the microsphere technique. Of the drugs tested, reserpine was the only one to cause a significant increase in cutaneous blood flow. Previous clinical and experimental studies on the treatment of failing skin flaps are reviewed. The important criteria for designing future pharmacologic studies are discussed.
对带有随机皮瓣的猪使用酚苄明、异舒普林或利血平进行治疗。未检测到皮瓣存活率有显著提高。在选定的动物中，使用微球技术测量皮肤血流量。在所测试的药物中，利血平是唯一能使皮肤血流量显著增加的药物。本文回顾了以往关于治疗失败皮瓣的临床和实验研究。讨论了设计未来药理学研究的重要标准。
