Jurell G, Jonsson C E
Scand J Plast Reconstr Surg. 1976;10(3):169-72. doi: 10.3109/02844317609012964.
The effect upon the survival of skin flaps of several drugs which affect the adrenergic system was studied in rats. In control animals 41% of the skin flaps had survived seven days after the operation. Reserpine (1 mg/kg) injected intraperitoneally (i.p.) three days and one day before the flap operation increased the surviving flap area by 75% (p less than 0.001) as compared to control rats injected with saline. I.p. injection of guanethidine (5 mg/kg) or bretylium (10 mg/kg) every 12 hours, starting 24 hours before surgery and continued for 5 consecutive days, also increased the surviving flap area (19 and 33% respectively p less than 0.001). The surviving flap area was unchanged when desipramine (5 mg/kg) was injected in the same way and was decreased by 15% (p less than 0.05) following i.p. injection of the MAO inhibitor pheniprazine (5 mg/kg). Treatment with alpha-methyl-p-tyrosine (75 mg/kg), i.p. 30 min before surgery or 6-hydroxydopamine (50 mg/kg) i.v. 24 hours prior to surgery also increased the flap survival (56 and 49% increase in surviving flap area, respectively, p less than 0.001). The results demonstrated that the survival of skin flaps increased when the function of the adrenergic nervous system was inhibited. Enhanced sympathetic nervous activity slightly reduced or did not affect skin flap survival.
在大鼠中研究了几种影响肾上腺素能系统的药物对皮瓣存活的作用。在对照动物中，41%的皮瓣在手术后7天存活。在皮瓣手术前3天和1天腹腔注射利血平（1mg/kg），与注射生理盐水的对照大鼠相比，皮瓣存活面积增加了75%（p<0.001）。从手术前24小时开始，每12小时腹腔注射胍乙啶（5mg/kg）或溴苄铵（10mg/kg），并连续进行5天，皮瓣存活面积也增加（分别为19%和33%，p<0.001）。以同样方式注射地昔帕明（5mg/kg）时，皮瓣存活面积未改变，而腹腔注射单胺氧化酶抑制剂苯乙肼（5mg/kg）后，皮瓣存活面积减少了15%（p<0.05）。在手术前30分钟腹腔注射α-甲基-对-酪氨酸（75mg/kg）或在手术前24小时静脉注射6-羟基多巴胺（50mg/kg）也增加了皮瓣存活（皮瓣存活面积分别增加56%和49%，p<0.001）。结果表明，当肾上腺素能神经系统功能被抑制时，皮瓣存活增加。增强的交感神经活动略微降低或不影响皮瓣存活。
