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毒理学中基因组技术的最新进展:综述。

State of the Art of Genomic Technology in Toxicology: A Review.

机构信息

Environmental Health Unit-PEÑOLES, Torreòn 27220, Mexico.

Laboratory of Environmental Health, School of Chemical Sciences, Juarez University of Durango State, Gomez Palacio 35010, Mexico.

出版信息

Int J Mol Sci. 2023 Jun 1;24(11):9618. doi: 10.3390/ijms24119618.

Abstract

The rapid growth of genomics techniques has revolutionized and impacted, greatly and positively, the knowledge of toxicology, ushering it into a "new era": the era of genomic technology (GT). This great advance permits us to analyze the whole genome, to know the gene response to toxicants and environmental stressors, and to determine the specific profiles of gene expression, among many other approaches. The aim of this work was to compile and narrate the recent research on GT during the last 2 years (2020-2022). A literature search was managed using the PubMed and Medscape interfaces on the Medline database. Relevant articles published in peer-reviewed journals were retrieved and their main results and conclusions are mentioned briefly. It is quite important to form a multidisciplinary taskforce on GT with the aim of designing and implementing a comprehensive, collaborative, and a strategic work plan, prioritizing and assessing the most relevant diseases, so as to decrease human morbimortality due to exposure to environmental chemicals and stressors.

摘要

基因组学技术的快速发展彻底改变并积极影响了毒理学知识,将其带入了一个“新时代”:基因组技术(GT)时代。这一巨大进步使我们能够分析整个基因组,了解基因对毒物和环境应激源的反应,并确定特定的基因表达谱等。本工作旨在综述过去 2 年(2020-2022 年)GT 的最新研究。使用 PubMed 和 Medscape 界面在 Medline 数据库上进行文献检索。检索到发表在同行评议期刊上的相关文章,并简要提及它们的主要结果和结论。非常重要的是,组建一个关于 GT 的多学科工作组,旨在设计和实施一个全面的、协作的和战略性的工作计划,优先考虑和评估最相关的疾病,以降低由于暴露于环境化学物质和应激源而导致的人类发病率和死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33f8/10253724/e3a4fe17d814/ijms-24-09618-g001.jpg

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