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Nga-Mon（）鲜叶和干叶的生物功效：抗氧化、抗诱变和抗炎潜力评估。

Bioefficacy of Nga-Mon () Fresh and Dry Leaf: Assessment of Antioxidant, Antimutagenicity, and Anti-Inflammatory Potential.

作者信息

Tantipaiboonwong Payungsak, Pintha Komsak, Chaiwangyen Wittaya, Suttajit Maitree, Khanaree Chakkrit, Khantamat Orawan

机构信息

Division of Biochemistry, School of Medical Sciences, University of Phayao, Phayao 56000, Thailand.

School of Traditional and Alternative Medicine, Chiang Rai Rajabhat University, Chiang Rai 57100, Thailand.

出版信息

Plants (Basel). 2023 Jun 3;12(11):2210. doi: 10.3390/plants12112210.

DOI:10.3390/plants12112210
PMID:37299189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10255129/
Abstract

Perilla leaves are known to be a rich source of polyphenols, which have been shown to exhibit various biological effects. This study aimed to compare the bioefficacies and bioactivities of fresh (PLE) and dry (PLE) Thai perilla (Nga-mon) leaf extracts. Phytochemical analysis indicated that both PLE and PLE were abundant in rosmarinic acid and bioactive phenolic compounds. PLE, which had higher levels of rosmarinic acid but lower levels of ferulic acid and luteolin than PLE, exhibited greater effectiveness in a free radical scavenging assay. Furthermore, both extracts were found to suppress intracellular ROS generation and exhibit antimutagenic activity against food-borne carcinogens in . They also attenuated lipopolysaccharide-induced inflammation in RAW 264.7 cells by inhibiting the expression of nitric oxide, iNOS, COX-2, TNF-α, IL-1β, and IL-6 through the suppression of NF-κB activation and translocation. However, PLE exhibited a higher ability to suppress cellular ROS production and higher antimutagenic and anti-inflammatory activities than PLE, which can be attributed to its combination of phytochemical components. Overall, PLE and PLE have the potential to serve as natural bioactive antioxidant, antimutagenic, and anti-inflammatory agents to achieve potential health benefits.

摘要

紫苏叶是已知的丰富多酚来源，已显示出具有多种生物学效应。本研究旨在比较新鲜（PLE）和干燥（PLE）泰国紫苏（Nga-mon）叶提取物的生物功效和生物活性。植物化学分析表明，PLE和PLE均富含迷迭香酸和生物活性酚类化合物。与PLE相比，迷迭香酸含量较高但阿魏酸和木犀草素含量较低的PLE在自由基清除试验中表现出更高的有效性。此外，两种提取物均能抑制细胞内活性氧的产生，并对食品中的致癌物表现出抗诱变活性。它们还通过抑制NF-κB的激活和转位，抑制一氧化氮、诱导型一氧化氮合酶、环氧化酶-2、肿瘤坏死因子-α、白细胞介素-1β和白细胞介素-6的表达，从而减轻脂多糖诱导的RAW 264.7细胞炎症。然而，PLE比PLE表现出更高的抑制细胞活性氧产生的能力以及更高的抗诱变和抗炎活性，这可归因于其植物化学成分的组合。总体而言，PLE和PLE有潜力作为天然生物活性抗氧化剂、抗诱变剂和抗炎剂，以实现潜在的健康益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/d5f2827e6235/plants-12-02210-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/a55fc6fa1058/plants-12-02210-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/99d55cbc82f1/plants-12-02210-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/21da11f61d0e/plants-12-02210-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/38d2d7e65ae0/plants-12-02210-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/fa246e83c37a/plants-12-02210-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/901e7c86b1c0/plants-12-02210-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/8a156d244a55/plants-12-02210-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/848cd08450fb/plants-12-02210-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/d5f2827e6235/plants-12-02210-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/a55fc6fa1058/plants-12-02210-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/99d55cbc82f1/plants-12-02210-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/21da11f61d0e/plants-12-02210-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/38d2d7e65ae0/plants-12-02210-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/fa246e83c37a/plants-12-02210-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/901e7c86b1c0/plants-12-02210-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/8a156d244a55/plants-12-02210-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/848cd08450fb/plants-12-02210-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0b4/10255129/d5f2827e6235/plants-12-02210-g009.jpg

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