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红参马克西酊的制备及其作为皮肤营养素的应用。

Preparation of Red Ginseng Marc-Derived Gintonin and Its Application as a Skin Nutrient.

机构信息

Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.

Department of Life Science, University of Seoul, Seoul 02504, Republic of Korea.

出版信息

Nutrients. 2023 May 31;15(11):2574. doi: 10.3390/nu15112574.

DOI:10.3390/nu15112574
PMID:37299538
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10255325/
Abstract

Ginseng is one of the traditional herbal medicines for tonic. Gintonin is a new material derived from white/red ginseng and its lysophosphatidic acids (LPAs) play as a ligand for G protein-coupled LPA receptors. Korean red ginseng marc (KRGM) is a by-product after the KRG processes. We developed a low-cost/high-efficiency method for KRGM gintonin production. We further studied the KRGM gintonin-mediated anti-skin aging effects under UVB exposure using human dermal fibroblasts (HDFs). KRGM gintonin yield is about 8%. KRGM gintonin contains a high amount of LPA C, lysophosphatidylcholine (LPC), and phosphatidylcholine (PC), which is similar to white ginseng gintonin. KRGM gintonin induced [Ca] transient via LPA1/3 receptors and increased cell viability/proliferation under UVB exposure. The underlying mechanisms of these results are associated with the antioxidant action of KRGM gintonin. KRGM gintonin attenuated UVB-induced cell senescence by inhibiting cellular β-galactosidase overexpression and facilitated wound healing. These results indicate that KRGM can be a novel bioresource of KRGM gintonin, which can be industrially utilized as new material for skin nutrition and/or skin healthcare.

摘要

人参是一种传统的滋补草药。Gintonin 是一种从白/红参及其溶血磷脂酸（LPAs）衍生而来的新材料，作为 G 蛋白偶联 LPA 受体的配体发挥作用。高丽红参渣（KRGM）是 KRG 加工后的副产品。我们开发了一种从 KRGM 中高效低成本生产 Gintonin 的方法。我们进一步研究了 KRGM Gintonin 在 UVB 暴露下对人真皮成纤维细胞（HDFs）的抗皮肤衰老作用。KRGM Gintonin 的产量约为 8%。KRGM Gintonin 含有大量的 LPA C、溶血磷脂酰胆碱（LPC）和磷脂酰胆碱（PC），这与白参 Gintonin 相似。KRGM Gintonin 通过 LPA1/3 受体诱导[Ca]瞬变，并在 UVB 暴露下增加细胞活力/增殖。这些结果的潜在机制与 KRGM Gintonin 的抗氧化作用有关。KRGM Gintonin 通过抑制细胞β-半乳糖苷酶的过表达和促进伤口愈合来减轻 UVB 诱导的细胞衰老。这些结果表明，KRGM 可以作为一种新型的 KRGM Gintonin 生物资源，可作为皮肤营养和/或皮肤保健的新材料在工业上加以利用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0520/10255325/fc116a04c298/nutrients-15-02574-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0520/10255325/e3b829816a9f/nutrients-15-02574-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0520/10255325/e82fb5e3671e/nutrients-15-02574-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0520/10255325/60240872c809/nutrients-15-02574-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0520/10255325/eb4ede13ca40/nutrients-15-02574-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0520/10255325/2ca5f39f4662/nutrients-15-02574-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0520/10255325/fc116a04c298/nutrients-15-02574-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0520/10255325/e3b829816a9f/nutrients-15-02574-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0520/10255325/e82fb5e3671e/nutrients-15-02574-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0520/10255325/60240872c809/nutrients-15-02574-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0520/10255325/eb4ede13ca40/nutrients-15-02574-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0520/10255325/2ca5f39f4662/nutrients-15-02574-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0520/10255325/fc116a04c298/nutrients-15-02574-g006.jpg

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