Research Institute of Biotechnology and Medical Converged Science, Dongguk University-Seoul, Goyang-si, Republic of Korea.
Department of Food Science and Biotechnology and Food and Bio Safety Research Center, Dongguk University-Seoul, Goyang-si, Republic of Korea.
J Food Biochem. 2019 Aug;43(8):e12961. doi: 10.1111/jfbc.12961. Epub 2019 Jun 30.
Red Ginseng is well-known functional food in Asia which is produced by steaming and drying fresh ginseng (Panax ginseng). In the production of red ginseng extract, around 65% of the original material is left over as by-product and discarded. Most studies on ginseng are focused on ginsenosides. Many functional substances other than ginsenoside are found in red ginseng, but they have not been studied and are usually discarded. Acidic polysaccharides, which are functional polysaccharides found in the by-product of red ginseng, can be utilized as excellent high-value-added material. In this study, we developed red ginseng by-product polysaccharides (RGBPs) by applying an enzyme-linked high-pressure process (ELHPP). We have demonstrated the antioxidant, anti-aging, and anti-atopic dermatitis efficacy of ELHPP-RGBPs in this study. In acute oral toxicity and skin irritation tests, ELHPP-RGBPs were found to be very low in toxicity. ELHPP-RGBPs inhibited solar ultraviolet-induced matrix metalloproteinase-1 (MMP-1) protein through activator protein-1 (AP-1), a major transcription factor for MMP-1. ELHPP-RGBP attenuated DFE-induced AD-like symptoms as assessed by skin lesion analyses, dermatitis score, and skin thickness. Taken together, these results suggest that ELHPP-RGBP may have potential as a nutraceutical ingredient for skin health. PRACTICAL APPLICATIONS: This paper presents a new method of using ginseng by-product that has not been used and discarded. The use of polysaccharides in ginseng by-product has been shown to prevent skin wrinkles and atopic dermatitis. This is an economical new functional food material.
红参是亚洲著名的功能性食品，由新鲜人参（人参）经过蒸煮和干燥制成。在红参提取物的生产过程中，约 65%的原材料作为副产物剩余并被丢弃。大多数人参研究都集中在人参皂苷上。除了人参皂苷外，红参中还发现了许多其他具有功能的物质，但这些物质尚未得到研究，通常会被丢弃。酸性多糖是红参副产物中发现的功能性多糖，可用作优质的高附加值材料。在这项研究中，我们通过应用酶联高压工艺（ELHPP）开发了红参副产物多糖（RGBPs）。我们在这项研究中证明了 ELHPP-RGBPs 的抗氧化、抗衰老和抗特应性皮炎功效。在急性口服毒性和皮肤刺激性试验中，ELHPP-RGBPs 的毒性非常低。ELHPP-RGBPs 通过激活蛋白-1（AP-1）抑制了太阳紫外线诱导的基质金属蛋白酶-1（MMP-1）蛋白，AP-1 是 MMP-1 的主要转录因子。ELHPP-RGBP 减轻了 DFE 诱导的 AD 样症状，如皮肤损伤分析、皮炎评分和皮肤厚度评估。综上所述，这些结果表明，ELHPP-RGBP 可能具有作为皮肤健康营养成分的潜力。 实际应用：本文提出了一种使用尚未使用和丢弃的人参副产物的新方法。在人参副产物中使用多糖已被证明可预防皮肤皱纹和特应性皮炎。这是一种经济实惠的新型功能性食品材料。
