LIFE - Health and Biosciences Research Institute, Midwest Campus, Technological University of the Shannon, Limerick V94EC5T, Ireland; PRISM Research Institute, Midlands Campus, Technological University of the Shannon, Athlone N37 HD68, Ireland.
Department of Emergency and Intensive Care, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy; School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Microbiol Res. 2023 Sep;274:127424. doi: 10.1016/j.micres.2023.127424. Epub 2023 Jun 5.
β-glucans are a large class of complex polysaccharides found in abundant sources. Our dietary sources of β-glucans are cereals that include oats and barley, and non-cereal sources can consist of mushrooms, microalgae, bacteria, and seaweeds. There is substantial clinical interest in β-glucans; as they can be used for a variety of diseases including cancer and cardiovascular conditions. Suitable sources of β-glucans for biopharmaceutical applications include bacteria, microalgae, mycelium, and yeast. Environmental factors including culture medium can influence the biomass and ultimately β-glucan content. Therefore, cultivation conditions for the above organisms can be controlled for sustainable enhanced production of β-glucans. This review discusses the various sources of β-glucans and their cultivation conditions that may be optimised to exploit sustainable production. Finally, this article discusses the immune-modulatory potential of β-glucans from these sources.
β-葡聚糖是一类广泛存在于丰富来源中的复杂多糖。我们的β-葡聚糖膳食来源包括燕麦和大麦等谷物，而非谷物来源可以包括蘑菇、微藻、细菌和海藻。β-葡聚糖具有重要的临床意义，因为它们可用于多种疾病，包括癌症和心血管疾病。适合用于生物制药应用的β-葡聚糖的来源包括细菌、微藻、菌丝体和酵母。环境因素包括培养基可以影响生物量，最终影响β-葡聚糖含量。因此，可以控制上述生物体的培养条件，以实现可持续的β-葡聚糖生产。本文讨论了β-葡聚糖的各种来源及其培养条件，这些条件可以进行优化以实现可持续生产。最后，本文讨论了这些来源的β-葡聚糖的免疫调节潜力。
