对含磷酸钙颗粒的实验性复合材料中钙释放情况进行的一年监测。
One year monitoring of calcium release from an experimental composite containing calcium phosphate particles.
作者信息
Vilela Handially, Nakamura Mariana, Braga Roberto
机构信息
Department of Biomaterials and Oral Biology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
出版信息
Biomater Investig Dent. 2025 Aug 28;12:44586. doi: 10.2340/biid.v12.44586. eCollection 2025.
INTRODUCTION
Ca release from specimens made of a composite containing dicalcium phosphate dihydrate particles (CaHPO.2HO, dicalcium phosphate dihydrate [DCPD]) was followed during 1 year.
METHODS
Specimens were individually immersed in deionized water ( = 3). Every 2 weeks, immersion medium was collected and specimens were transferred to new vials with fresh medium. Ca release was quantified using induced coupled plasma-optical emission spectrometry (ICP-OES). Data were analyzed by ANOVA/Tukey test (alpha: 5%).
RESULTS
Ca release was observed during the entire 12-month period. Cumulative release was 1635.1 ± 145.3 μg/cm (179.7 ± 16.0 ppm), corresponding to 23.8 ± 2.0% of the total Ca mass in the specimen.
CONCLUSION
The tested composite was capable of sustained Ca release in water for 1 year. In spite of the limitations of this screening test, the results suggest that composites containing Calcium phosphate (CaP) particles could offer a long-term Ca supply to the adjacent dental tissues.
引言
在1年的时间里，对含有二水磷酸二钙颗粒（CaHPO₄·2H₂O，二水磷酸二钙[DCPD]）的复合材料制成的标本中的钙释放情况进行了跟踪研究。
方法
将标本分别浸入去离子水中（n = 3）。每2周收集一次浸泡介质，并将标本转移到装有新鲜介质的新小瓶中。使用电感耦合等离子体发射光谱法（ICP - OES）对钙释放进行定量分析。数据通过方差分析/ Tukey检验进行分析（α：5%）。
结果
在整个12个月期间均观察到钙释放。累积释放量为1635.1±145.3μg/cm²（179.7±16.0ppm），相当于标本中总钙质量的23.8±2.0%。
结论
所测试的复合材料能够在水中持续释放钙达1年。尽管该筛选试验存在局限性，但结果表明含有磷酸钙（CaP）颗粒的复合材料可为相邻的牙组织提供长期的钙供应。
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