Wong Nikita, Cascardo Camilla A, Mansour Meghan, Qian Victoria, Potts Geoffrey A
Dermatology, Wayne State University School of Medicine, Detroit, USA.
Medicine, Oakland University William Beaumont School of Medicine, Rochester, USA.
Cureus. 2023 May 9;15(5):e38772. doi: 10.7759/cureus.38772. eCollection 2023 May.
Pityriasis rosea (PR) is an acute exanthematous disease, commonly preceded by a primary solitary herald patch followed by the onset of smaller scaly papulosquamous lesions within days to weeks. The exact cause of PR remains unclear; however, rash eruptions are thought to be associated with systemic reactivation of human herpesvirus 6 and 7 (HHV-6/7). Several cutaneous manifestations, including PR, have been reported secondary to SARS-CoV-2 infection and/or COVID-19 vaccination. The purpose of this review is to synthesize available data regarding PR in close association with SARS-CoV-2/COVID-19 infection and/or vaccination. A total of 154 patients were included in this study with 62 females and 50 males. PR was reported to occur more commonly in association with SARS-CoV-2/COVID-19 vaccination (102, 66.2%) than during infection (22, 42.3%) or post-infection (30, 57.7%). Interestingly, only 7.1% of patients were tested for concomitant HHV-6/7 past or current infection, with 4.2% testing positive or reporting a history of roseola infantum. While rare, clinicians should be aware of the possibility of patients developing PR associated with SARS-CoV-2/COVID-19 infection and/or vaccination, among other cutaneous reactions. Future studies exploring the link between PR and SARS-CoV-2/COVID-19 infection and/or vaccination would be beneficial, including direct examination of tissue and serological studies for evidence of COVID-19-induced HHV-6/7 reactivation.
玫瑰糠疹（PR）是一种急性发疹性疾病，通常先出现一个原发性孤立的先驱斑，随后在数天至数周内出现较小的鳞屑性丘疹鳞屑性损害。PR的确切病因尚不清楚；然而，皮疹发作被认为与人类疱疹病毒6型和7型（HHV-6/7）的全身再激活有关。包括PR在内的几种皮肤表现已被报道继发于严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染和/或2019冠状病毒病（COVID-19）疫苗接种。本综述的目的是综合与SARS-CoV-2/COVID-19感染和/或疫苗接种密切相关的关于PR的现有数据。本研究共纳入154例患者，其中女性62例，男性50例。据报道，PR与SARS-CoV-2/COVID-19疫苗接种（102例，66.2%）相关的发生率高于感染期间（22例，42.3%）或感染后（30例，57.7%）。有趣的是，只有7.1%的患者接受了HHV-6/7既往或当前感染的检测，4.2%检测呈阳性或报告有幼儿急疹病史。虽然罕见，但临床医生应意识到患者出现与SARS-CoV-2/COVID-19感染和/或疫苗接种相关的PR以及其他皮肤反应的可能性。未来探索PR与SARS-CoV-2/COVID-19感染和/或疫苗接种之间联系的研究将是有益的，包括对组织的直接检查和血清学研究，以寻找COVID-19诱导HHV-6/7再激活的证据。
