艾灸改善了小鼠与年龄相关的神经行为和肠道微生物群的改变。
Moxibustion ameliorated age-related alterations in neurological behavior and gut microbiota in mice.
作者信息
Lin Yao, Xing Min, Liu Nan, Ouyang Xia-Li, He Rui, Huang Chang, Yao Qin, Liu Ya-Jie, Huang Yue-Ping, Xue Ying, Wang Zhong-Yu, Yang Dan-Chen, Han Li, Zhao Bai-Xiao
机构信息
School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine Beijing 102488, PR China.
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine Beijing 102488, PR China.
出版信息
Am J Transl Res. 2023 May 15;15(5):3172-3187. eCollection 2023.
OBJECTIVE
To observe the anti-aging effects of moxibustion on age-related alterations in middle-aged mice.
METHODS
Thirty, 9-month-old, male ICR mice were randomly divided into the moxibustion and control groups (N = 15). Mice in the moxibustion group were given mild moxibustion at the Guanyuan acupoint for 20 minutes every other day. After 30 treatments, neurobehavior tests, lifespan, gut microbiota composition and splenic gene expression were observed in the mice.
RESULTS
Moxibustion improved the locomotor activity as well as motor function, activated the SIRT1-PPARα signaling pathway, ameliorated age-related alterations in gut microbiota, and affected the expression of genes related to energy metabolism in spleen.
CONCLUSION
Moxibustion ameliorated age-related alterations in neurobehavior and gut microbiota in middle-aged mice.
目的
观察艾灸对中年小鼠衰老相关改变的抗衰老作用。
方法
将30只9月龄雄性ICR小鼠随机分为艾灸组和对照组（每组15只）。艾灸组小鼠每隔一天在关元穴进行温和艾灸20分钟。30次治疗后，观察小鼠的神经行为测试、寿命、肠道微生物群组成和脾脏基因表达。
结果
艾灸改善了运动活动和运动功能，激活了SIRT1-PPARα信号通路，改善了与年龄相关的肠道微生物群改变，并影响了脾脏中与能量代谢相关基因的表达。
结论
艾灸改善了中年小鼠与年龄相关的神经行为和肠道微生物群改变。
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