Teker Hikmet Taner, Ceylani Taha
Department of Medical Biology and Genetics, Ankara Medipol University, Ankara, Turkey.
Department of Food Quality Control and Analysis, Muş Alparslan University, Muş, Turkey.
Int Microbiol. 2023 Jan;26(1):51-57. doi: 10.1007/s10123-022-00272-7. Epub 2022 Aug 11.
There is a growing body of detailed research demonstrating that intermittent fasting is essentially a cleansing activity in terms of health. Especially since its applications that exceed 16 h trigger autophagy, it continues its effect on all tissue and organ systems after the regeneration movement that starts at the cellular level. Similarly, it continues to be better understood with each passing day that the gut microbiota (GM) has many positive effects on all tissue and organ systems. Although the GM is affected by many different parameters, dietary habits are reported to be the most effective factor. Therefore, it is important to investigate the effects of different preferred fasting practices on the GM, which has numerous health benefits. Pointing out this situation, this study aims to determine the effects of 18-h intermittent fasting for 5 weeks on the shaping of GM. A 12-month-old male Wistar rat was chosen as the model organism in the study. At the end of the application, the metagenome was applied to the cecum content of the intestinal tissue collected from the sacrificed animals. Intermittent fasting practice led to an increase in alpha diversity, which expresses a significant bacterial diversity, the stabilization of Firmicutes and Bacteroidetes ratios (F/B), and the reshaping of the values with the highest prevalence in all stages of the classification, especially in the family, genus, and species care. Analysis results showed that the preferred intermittent fasting program helps balance the GM composition. This study is an important example showing the strong positive link between intermittent fasting and GM.
越来越多的详细研究表明，就健康而言，间歇性禁食本质上是一种净化活动。特别是由于其超过16小时的禁食应用会引发自噬，它在从细胞水平开始的再生运动后，会持续对所有组织和器官系统产生影响。同样，人们日益清楚地认识到，肠道微生物群（GM）对所有组织和器官系统都有许多积极影响。尽管肠道微生物群受许多不同参数的影响，但据报道饮食习惯是最有效的因素。因此，研究不同的偏好禁食方式对具有众多健康益处的肠道微生物群的影响很重要。指出这种情况后，本研究旨在确定为期5周的18小时间歇性禁食对肠道微生物群形成的影响。研究中选择了一只12个月大的雄性Wistar大鼠作为模式生物。在应用结束时，对从处死动物收集的肠道组织盲肠内容物进行宏基因组分析。间歇性禁食导致表示显著细菌多样性的α多样性增加、厚壁菌门和拟杆菌门比例（F/B）稳定，以及在分类的所有阶段，尤其是在科、属和种层面，流行率最高的值发生重塑。分析结果表明，偏好的间歇性禁食方案有助于平衡肠道微生物群组成。这项研究是一个重要例子，表明间歇性禁食与肠道微生物群之间存在紧密的积极联系。
