Khitrov N K, Toloknov A V, Bol'shakova T D, Vinnitskaia K B, Panteleĭmonov V A
Biull Eksp Biol Med. 1986 Jun;101(6):655-8.
4% CO2 addition to normoxic gas medium increased the activity, mass and functional capacity of the left ventricular myocardium, enhanced the stability of acetylcholine (AC) and noradrenaline (NA) storage in the myocardial tissues and stimulated myocardial response to these mediators during physical training of rats (swimming for 2 months). When the duration of the training period was prolonged to 3 months, CO2 had a decreasing effect on the myocardial activity, AC concentration and storage stability, as well as on the myocardial response to AC. The possibility of reducing signal and increasing metabolic CO2 effects during physical training is considered. The importance of intensified heart regulation by sympathetic and parasympathetic mechanisms during adaptation and the role of mechanism dissociation with the decrease in the degree of adaptation are discussed.
在常氧气体介质中添加4%的二氧化碳可增加大鼠左心室心肌的活性、质量和功能能力，增强心肌组织中乙酰胆碱（AC）和去甲肾上腺素（NA）储存的稳定性，并在大鼠进行2个月游泳体能训练期间刺激心肌对这些介质的反应。当训练期延长至3个月时，二氧化碳对心肌活性、AC浓度和储存稳定性以及心肌对AC的反应产生降低作用。文中考虑了在体能训练期间降低信号和增加代谢性二氧化碳作用的可能性。讨论了在适应过程中通过交感和副交感机制加强心脏调节的重要性以及随着适应程度降低机制解离的作用。
