Li Yiling, Gong Fengyuan, Guo Yangyang, Xu Xianrong, Wang Cuicui, Jin Zhanguo
Air Force Clinical College, The Fifth School of Clinical Medicine, Anhui Medical University, Hefei, Anhui, China.
Vertigo Clinic/Research Center of Aerospace Medicine, Air Force Medical Center, PLA, Beijing, China.
Front Neurol. 2023 May 25;14:1194456. doi: 10.3389/fneur.2023.1194456. eCollection 2023.
This study aimed to investigate the effect of vascular risk factors on the outcomes of endolymphatic sac decompression (ESD) surgery in patients with Meniere's disease.
The study included 56 patients with Meniere's disease, who had undergone unilateral ESD surgery. The patients' vascular risk factors were assessed based on the preoperative 10-year atherosclerotic cardiovascular diseases risk classification. Those with no or low risk were defined as the low-risk group, while those with medium, high, or very high risk were defined as the high-risk group. The correlation between the vascular risk factors and ESD efficacy was evaluated by the comparison of vertigo control grade between the two groups. The functional disability score was also assessed to investigate whether ESD improved the quality of life in Meniere's disease patients with vascular risk factors.
After ESD, 78.95 and 81.08% of patients from the low-risk and high-risk groups, respectively, demonstrated at least grade B vertigo control; no statistically significant difference was observed ( = 0.96). The postoperative functional disability scores in both groups were significantly lower compared with those before surgery ( < 0.01), with a median decrease of two (1, 2) points in both groups. No statistically significant difference between the two groups was observed ( = 0.65).
Vascular risk factors have little effect on the efficacy of ESD in patients with Meniere's disease. Patients with one or more vascular risk factors can still experience a not poor vertigo control and improved quality of life after ESD.
本研究旨在探讨血管危险因素对梅尼埃病患者内淋巴囊减压术（ESD）手术效果的影响。
该研究纳入了56例行单侧ESD手术的梅尼埃病患者。根据术前10年动脉粥样硬化性心血管疾病风险分类评估患者的血管危险因素。无风险或低风险者定义为低风险组，中度、高度或极高风险者定义为高风险组。通过比较两组眩晕控制等级来评估血管危险因素与ESD疗效之间的相关性。还评估了功能残疾评分，以调查ESD是否改善了有血管危险因素的梅尼埃病患者的生活质量。
ESD术后，低风险组和高风险组分别有78.95%和81.08%的患者眩晕控制至少达到B级；未观察到统计学上的显著差异（=0.96）。两组术后功能残疾评分均显著低于术前（<0.01），两组中位数均下降2（1，2）分。两组之间未观察到统计学上的显著差异（=0.65）。
血管危险因素对梅尼埃病患者ESD的疗效影响不大。有一个或多个血管危险因素的患者在ESD术后仍可获得较好的眩晕控制并改善生活质量。
