Department of Cell Biology and Histology, School of Biology, Lomonosov Moscow State University, Moscow, Russia.
Moscow Department of Healthcare, City Clinical Hospital Named After I.V. Davydovsky, Moscow, Russia.
Ultrastruct Pathol. 2023 Sep 3;47(5):382-387. doi: 10.1080/01913123.2023.2222167. Epub 2023 Jun 12.
Recent studies indicate that cilia impairment, accompanied by the axonema loss and the basal body misorientation, is a common pathological feature of SARS-CoV-2-infected bronchial epithelial cells. However, these data were obtained using either cultured cells, or animal models, while in human postmortem material, cilia impairment has not been described yet. Here, we present direct observation of cilia impairment in SARS-CoV-2-infected bronchial epithelial cells using transmission electron microscopy of the autopsy material. We were able to observe only single infected cells with cilia impairment in one of twelve examined specimens, while the large number of desquamated bronchial epithelial cells with undisturbed ciliary layer was visible in the bronchial lumens. Thus, it seems that in the lungs of infected patients, the majority of bronchial cells do not die as a direct result of infection, which may explain the rarity of this finding in the autopsy material.
最近的研究表明，纤毛损伤伴随着轴丝丧失和基体取向错误，是 SARS-CoV-2 感染的支气管上皮细胞的共同病理特征。然而，这些数据是使用培养细胞或动物模型获得的，而在人类尸检材料中，尚未描述纤毛损伤。在这里，我们使用尸检材料的透射电子显微镜直接观察到 SARS-CoV-2 感染的支气管上皮细胞中的纤毛损伤。我们仅在 12 个检查标本中的 1 个中观察到单个感染细胞的纤毛损伤，而在支气管腔中可见大量脱落的支气管上皮细胞，其纤毛层未受干扰。因此，似乎在感染患者的肺部中，大多数支气管细胞不会直接因感染而死亡，这可能解释了在尸检材料中这种发现罕见的原因。
