海洋 sp. 蓝藻来源的奥卡酰胺 A 和 B 对前体脂肪细胞的诱导分化作用。
Differentiation-Promoting Effects of Okeaniamides A and B from an sp. Marine Cyanobacterium on Preadipocytes.
机构信息
Graduate School of Engineering and Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
Department of Material and Life Chemistry, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan.
出版信息
J Nat Prod. 2023 Jun 23;86(6):1564-1570. doi: 10.1021/acs.jnatprod.3c00256. Epub 2023 Jun 12.
The linear lipopeptides okeaniamide A () and okeaniamide B () were isolated from an sp. marine cyanobacterium collected in Okinawa. The structures of these compounds were established by spectroscopic analyses, and the absolute configurations were elucidated based on a combination of chemical degradations, Marfey's analysis, and derivatization reactions. Okeaniamide A () and okeaniamide B () dose-dependently promoted the differentiation of mouse 3T3-L1 preadipocytes in the presence of insulin.
线性脂肽 okelamide A()和 okelamide B()从冲绳采集的海洋蓝藻中分离得到。通过光谱分析确定了这些化合物的结构，并基于化学降解、Marfey 分析和衍生化反应的组合确定了它们的绝对构型。Okeaniamide A()和 okeaniamide B()在胰岛素存在的情况下剂量依赖性地促进了小鼠 3T3-L1 前脂肪细胞的分化。
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