Department of Chemistry, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi , Kohoku-ku, Yokohama , Kanagawa 223-8522 , Japan.
Department of Biosciences and Informatics, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi , Kohoku-ku, Yokohama , Kanagawa 223-8522 , Japan.
J Nat Prod. 2020 Feb 28;83(2):481-488. doi: 10.1021/acs.jnatprod.9b01147. Epub 2020 Feb 10.
An antimalarial lipopeptide, ikoamide, was isolated from an sp. marine cyanobacterium. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral-phase HPLC analyses, spectroscopic analyses, and derivatization reactions. Ikoamide showed strong antimalarial activity with an IC value of 0.14 μM without cytotoxicity against human cancer cell lines at 10 μM.
从一种 sp. 海洋蓝细菌中分离到一种抗疟脂肽，伊考酰胺。通过光谱分析确定了它的大致结构，并通过手性相 HPLC 分析、光谱分析和衍生化反应的组合确定了它的绝对构型。伊考酰胺表现出很强的抗疟活性，IC 值为 0.14 μM，在 10 μM 时对人癌细胞系没有细胞毒性。
