Huff F J, Corkin S, Growdon J H
Brain Lang. 1986 Jul;28(2):235-49. doi: 10.1016/0093-934x(86)90103-3.
Impairment in naming visually presented objects was investigated in patients with a clinical diagnosis of Alzheimer's disease. Impaired object naming correlated with difficulty listing the names of objects from a specified semantic category and with erroneous selection of words semantically related to the correct names for objects in a name recognition test. These results suggest that patients with Alzheimer's disease have a semantic impairment characterized by inability to distinguish among objects that are members of the same semantic category, and that this impairment is associated with difficulty producing the names for objects. Semantic impairment was present in patients with normal ability to discriminate visually presented shapes, indicating that the semantic deficit in Alzheimer's disease occurs independently of abnormalities of visuospatial function. Patients tended to make errors on the same items in both confrontation naming and name recognition tests, suggesting that the semantic impairment in Alzheimer's disease involves loss of information about specific objects and their names.
对临床诊断为阿尔茨海默病的患者进行了视觉呈现物体命名障碍的研究。物体命名受损与从特定语义类别中列出物体名称困难以及在名称识别测试中错误选择与物体正确名称语义相关的单词有关。这些结果表明，阿尔茨海默病患者存在语义障碍，其特征是无法区分属于同一语义类别的物体，并且这种障碍与物体命名困难有关。语义障碍出现在视觉呈现形状辨别能力正常的患者中，这表明阿尔茨海默病中的语义缺陷独立于视觉空间功能异常而发生。患者在面对面命名和名称识别测试中倾向于在相同项目上出错，这表明阿尔茨海默病中的语义障碍涉及特定物体及其名称信息的丧失。
