Brockman S K, Younkin S G
Brain Res. 1986 Jun 25;376(2):409-11. doi: 10.1016/0006-8993(86)90210-6.
We have measured acetylcholinesterase (AChE) turnover and secretion in spontaneously fibrillating rat myotubes and in cultures in which fibrillation was blocked with tetrodotoxin. The rate at which AChE appeared in the medium was 4 times greater in fibrillating than in non-fibrillating cultures. In a 2-h interval, 32% of the AChE in fibrillating myotubes and 26% of the AChE in non-fibrillating myotubes turned over. In this interval, secreted AChE accounted for 28% and 16% of the AChE turnover that occurred in fibrillating and non-fibrillating myotubes, respectively.
我们已经测量了自发颤动的大鼠肌管以及用河豚毒素阻断颤动的培养物中的乙酰胆碱酯酶（AChE）周转和分泌情况。AChE出现在培养基中的速率在颤动的培养物中比在非颤动的培养物中快4倍。在2小时的时间段内，颤动肌管中32%的AChE以及非颤动肌管中26%的AChE发生了周转。在此时间段内，分泌的AChE分别占颤动和非颤动肌管中发生的AChE周转的28%和16%。
