From the Department of Neurology (N.T., B.K.C., F.A., S.J.P., E.P.F.), Mayo Clinic, Rochester, MN; Childrens Hospital Colorado (R.K.); Anschutz Medical Campus (A.D.), University of Colorado; and Colorado Permanente Medical Group (S.J.C.), Denver, CO.
Neurol Neuroimmunol Neuroinflamm. 2023 Jun 13;10(4). doi: 10.1212/NXI.0000000000200128. Print 2023 Jul.
Jaw dystonia and laryngospasm in the context of subacute brainstem dysfunction have been described in a small number of diseases, including antineuronal nuclear antibody type 2 (ANNA-2, also known as anti-Ri) paraneoplastic neurologic syndrome. Severe episodes of laryngospasms causing cyanosis are potentially fatal. Jaw dystonia can also cause eating difficulty, resulting in severe weight loss and malnutrition. In this report, we highlight the multidisciplinary management of this syndrome associated with ANNA-2/anti-Ri paraneoplastic neurologic syndrome and discuss its pathogenesis.
下颌痉挛和喉痉挛在少数疾病中伴有亚急性脑干功能障碍而被描述，包括抗神经元核抗体 2 型（ANNA-2，也称为抗 Ri）副肿瘤性神经综合征。严重的喉痉挛发作导致发绀可能是致命的。下颌痉挛也会导致进食困难，从而导致严重的体重减轻和营养不良。在本报告中，我们强调了与 ANNA-2/抗 Ri 副肿瘤性神经综合征相关的这种综合征的多学科管理，并讨论了其发病机制。
