Pokhrel Dilli Ram, Sah Manish Kumar, Gautam Bibaran, Basak Hriday Kumar, Bhattarai Ajaya, Chatterjee Abhik
Department of Chemistry, Damak Multiple Campus Damak Jhapa 57217 Nepal.
Department of Chemistry, Raiganj University Uttar Dinajpur West Bengal-733134 India
RSC Adv. 2023 Jun 12;13(26):17685-17704. doi: 10.1039/d3ra02883f. eCollection 2023 Jun 9.
This review focuses on the self-aggregation properties of different drugs, as well as on their interaction with anionic, cationic, and gemini surfactants. The interaction of drugs with surfactants has been reviewed concerning conductivity, surface tension, viscosity, density, and UV-Vis spectrophotometric measurements, and their relation with critical micelle concentration (CMC), cloud point, and binding constant. The conductivity measurement technique is used for the micellization of ionic surfactants. Cloud point studies can be used for the non-ionic, and also for certain ionic surfactants. Usually, surface tension studies are mostly employed for non-ionic surfactants. The degree of dissociation that is determined is used to evaluate thermodynamic parameters of micellization at various temperatures. The effect of external parameters like temperature, salt, solvent, pH, , is discussed for thermodynamics parameters using recent experimental works on drug-surfactant interactions. Consequences of drug-surfactant interaction, condition of drugs during interaction with surfactants, and applications of drug-surfactant interaction are being generalized which reflects current and future potential uses of drug-surfactant interactions.
本综述聚焦于不同药物的自聚集特性，以及它们与阴离子、阳离子和双子表面活性剂的相互作用。已针对电导率、表面张力、粘度、密度和紫外可见分光光度测量，以及它们与临界胶束浓度（CMC）、浊点和结合常数的关系，对药物与表面活性剂的相互作用进行了综述。电导率测量技术用于离子表面活性剂的胶束化。浊点研究可用于非离子表面活性剂，也可用于某些离子表面活性剂。通常，表面张力研究主要用于非离子表面活性剂。所确定的解离度用于评估不同温度下胶束化的热力学参数。利用近期关于药物 - 表面活性剂相互作用的实验工作，讨论了温度、盐、溶剂、pH等外部参数对热力学参数的影响。药物 - 表面活性剂相互作用的后果、药物与表面活性剂相互作用期间药物的状态，以及药物 - 表面活性剂相互作用的应用正在被归纳总结，这反映了药物 - 表面活性剂相互作用当前和未来的潜在用途。
