Khartade Prashant B, Taksande Amar, Meshram Revat, Uke Punam
Paediatrics, Jawaharlal Nehru Medical College, Sawangi Meghe, Wardha, IND.
Cureus. 2023 May 13;15(5):e38964. doi: 10.7759/cureus.38964. eCollection 2023 May.
Autoimmune hepatitis (AIH) is quite rare in children. AIH is classified into two types based on the presence of autoantibodies: type 1 and type 2. The presentation of AIH varies, ranging from asymptomatic to acute or chronic hepatitis and occasionally fulminant liver failure. It can present at any age. In 20% of AIH cases, other autoimmune disorders might be present, such as diabetes mellitus and arthritis. A high index of suspicion is required for the early diagnosis of this condition. Pediatricians should consider the possibility of AIH in patients with jaundice once common causes are ruled out. The diagnosis is done on the basis of the presence of typical autoantibody titer, liver biopsy findings, and response to immunosuppressive medications. Some AIH patients may not respond to immunosuppressive therapy and may need a liver transplant. We present a case of a 12-year-old male child with thalassemia trait who was diagnosed with AIH.
自身免疫性肝炎（AIH）在儿童中相当罕见。根据自身抗体的存在情况，AIH可分为两种类型：1型和2型。AIH的表现各不相同，从无症状到急性或慢性肝炎，偶尔也会出现暴发性肝衰竭。它可在任何年龄发病。在20%的AIH病例中，可能存在其他自身免疫性疾病，如糖尿病和关节炎。早期诊断这种疾病需要高度的怀疑指数。一旦排除常见病因，儿科医生应考虑黄疸患者患AIH的可能性。诊断基于典型自身抗体滴度的存在、肝活检结果以及对免疫抑制药物的反应。一些AIH患者可能对免疫抑制治疗无反应，可能需要进行肝移植。我们报告一例患有地中海贫血特征的12岁男童被诊断为AIH的病例。
