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丙泊酚对静脉镇静期间下颌下腺、舌下腺和唇腺唾液分泌的影响。

Effect of propofol on salivary secretion from the submandibular, sublingual, and labial glands during intravenous sedation.

作者信息

Masuda Keisuke, Furuyama Akira, Ohsuga Kenji, Abe Shota, Kawaai Hiroyoshi

机构信息

Department of Oral Function and Molecular Biology, Ohu University School of Dentistry, Fukushima, Japan.

Department of Dental Anesthesiology, Ohu University School of Dentistry, Fukushima, Japan.

出版信息

J Dent Anesth Pain Med. 2023 Jun;23(3):153-162. doi: 10.17245/jdapm.2023.23.3.153. Epub 2023 May 26.

DOI:10.17245/jdapm.2023.23.3.153
PMID:37313266
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10260352/
Abstract

BACKGROUND

Recent animal studies have suggested the role of GABA type A (GABA-) receptors in salivation, showing that GABA- receptor agonists inhibit salivary secretion. This study aimed to evaluate the effects of propofol (a GABA- agonist) on salivary secretions from the submandibular, sublingual, and labial glands during intravenous sedation in healthy volunteers.

METHODS

Twenty healthy male volunteers participated in the study. They received a loading dose of propofol 6 mg/kg/h for 10 min, followed by 3 mg/kg/h for 15 min. Salivary flow rates in the submandibular, sublingual, and labial glands were measured before, during, and after propofol infusion, and amylase activity was measured in the saliva from the submandibular and sublingual glands.

RESULTS

We found that the salivary flow rates in the submandibular, sublingual, and labial glands significantly decreased during intravenous sedation with propofol (P < 0.01). Similarly, amylase activity in the saliva from the submandibular and sublingual glands was significantly decreased (P < 0.01).

CONCLUSION

It can be concluded that intravenous sedation with propofol decreases salivary secretion in the submandibular, sublingual, and labial glands via the GABA- receptor. These results may be useful for dental treatment when desalivation is necessary.

摘要

背景

最近的动物研究表明γ-氨基丁酸A型（GABA-A）受体在唾液分泌中起作用，显示GABA-A受体激动剂可抑制唾液分泌。本研究旨在评估丙泊酚（一种GABA-A激动剂）对健康志愿者静脉镇静期间下颌下腺、舌下腺和唇腺唾液分泌的影响。

方法

20名健康男性志愿者参与了该研究。他们先接受10分钟6毫克/千克/小时的丙泊酚负荷剂量，随后15分钟接受3毫克/千克/小时的剂量。在丙泊酚输注前、期间和之后测量下颌下腺、舌下腺和唇腺的唾液流速，并测量下颌下腺和舌下腺唾液中的淀粉酶活性。

结果

我们发现，在丙泊酚静脉镇静期间，下颌下腺、舌下腺和唇腺的唾液流速显著降低（P < 0.01）。同样，下颌下腺和舌下腺唾液中的淀粉酶活性也显著降低（P < 0.01）。

结论

可以得出结论，丙泊酚静脉镇静通过GABA-A受体减少下颌下腺、舌下腺和唇腺的唾液分泌。这些结果对于需要减少唾液分泌的牙科治疗可能有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f9/10260352/13b43d4d9278/jdapm-23-153-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f9/10260352/854123e6efac/jdapm-23-153-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f9/10260352/d39a406045d5/jdapm-23-153-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f9/10260352/b4e87d7d60fb/jdapm-23-153-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f9/10260352/9e7addcf2c4f/jdapm-23-153-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f9/10260352/078d40d7298e/jdapm-23-153-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f9/10260352/a475789e2925/jdapm-23-153-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f9/10260352/13b43d4d9278/jdapm-23-153-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f9/10260352/854123e6efac/jdapm-23-153-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f9/10260352/d39a406045d5/jdapm-23-153-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f9/10260352/b4e87d7d60fb/jdapm-23-153-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f9/10260352/9e7addcf2c4f/jdapm-23-153-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f9/10260352/078d40d7298e/jdapm-23-153-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f9/10260352/a475789e2925/jdapm-23-153-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f9/10260352/13b43d4d9278/jdapm-23-153-g007.jpg

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