Liu Sizhe, Kang Le, Song Yagang, Miao Mingsan
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, People's Republic of China.
J Hepatocell Carcinoma. 2023 Jun 8;10:893-908. doi: 10.2147/JHC.S409292. eCollection 2023.
Recurrence of hepatocellular carcinoma (HCC) negatively affects the quality of life of patients and leads to death. Studies have shown that recurrent hepatocellular carcinoma (RHCC) is closely related to tissue hypoxia and autophagy. It has been shown that hypoxia-inducible factor-1α (HIF-1α) and its downstream factor BCL-2 19 kDa-interacting protein 3 (BNIP3) promote cellular autophagy under hypoxic conditions, resulting in metastasis and RHCC. In this article, the molecular structures of HIF-1α and BNIP3 are described, and the significance of the HIF-1α/BNIP3 signaling pathway in RHCC is explained. Moreover, the role and mechanism of traditional Chinese medicine (TCM) in treating RHCC by modulating the HIF-1α/BNIP3 signaling pathway is discussed. Studies have shown that the HIF-1α/BNIP3 signaling pathway is a potential target of TCM in the treatment of RHCC. The mechanism of the HIF-1α/BNIP3 signaling pathway in RHCC and the progress achieved in TCM research on targeting and regulating this pathway are also reviewed in this article. The objective was to provide a theoretical basis for the prevention and treatment of RHCC, as well as further drug development.
肝细胞癌（HCC）复发会对患者生活质量产生负面影响并导致死亡。研究表明，复发性肝细胞癌（RHCC）与组织缺氧和自噬密切相关。已有研究表明，缺氧诱导因子-1α（HIF-1α）及其下游因子BCL-2 19 kDa相互作用蛋白3（BNIP3）在缺氧条件下促进细胞自噬，从而导致转移和RHCC。本文描述了HIF-1α和BNIP3的分子结构，并解释了HIF-1α/BNIP3信号通路在RHCC中的意义。此外，还讨论了中药通过调节HIF-1α/BNIP3信号通路治疗RHCC的作用及机制。研究表明，HIF-1α/BNIP3信号通路是中药治疗RHCC的潜在靶点。本文还综述了HIF-1α/BNIP3信号通路在RHCC中的作用机制以及中药靶向调控该通路的研究进展。目的是为RHCC的防治及进一步的药物研发提供理论依据。
