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同型半胱氨酸、维生素B6、B12和叶酸与缺血性和出血性中风风险：来自印度东北部的一项病例对照研究。

Homocysteine, Vitamins B6, B12, and Folate and the Risk of Ischemic and Hemorrhagic Stroke: A Case-control Study from Northeast India.

作者信息

Ghose Manash, Das Madhumita, Das Rupjyoti, Barua Amit Ranjan, Deka Prasenjit, Barman Aparajita, Lahan Vivekananda, Choudhury Dhruba Jyoti, Sharma Jai Prakash, Mathur Manik, Borah Nomal Chandra, Choudhury Nupur, Barman Ananya

机构信息

Department of Neurology, GNRC Hospitals, Dispur, Guwahati, Assam, India.

Department of Biochemistry, GNRC Medical, North Guwahati, Assam, India.

出版信息

Ann Neurosci. 2023 Jan;30(1):33-39. doi: 10.1177/09727531221124425. Epub 2022 Oct 3.

DOI:10.1177/09727531221124425
PMID:37313333
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10259151/
Abstract

BACKGROUND

Stroke is a major leading global health complication. Identification and management of risk factors associated with stroke can help in prior detection, prevention, and improvement in patient care.

PURPOSE

To investigate the prevalence of hyperhomocysteinemia (HHcy) and Vitamins B6, B12, and folate deficiency in stroke patients and also to assess other risk factors associated with ischemic and hemorrhagic stroke.

METHODS

Detail history of all the subjects in the study including history of hypertension, anemia, fasting glucose, carotid artery thickness, smoking, alcohol, and dietary intake was recorded. Standard assays for homocysteine (Hcy), Vitamins B6, B12, and folate estimation were done. Lipid and renal profile tests were also performed. The prevalence and odds of having HHcy, Vitamins B6, B12, and folate deficiency, and other risk factors in ischemic and hemorrhagic stroke patients were evaluated. Student's -tests and chi-square tests were done for statistical validation of the data.

RESULTS

Prevalence of HHcy and Vitamins B6, B12, and folate deficiency was not observed in ischemic cases. HHcy and folate deficiency was found to be prevalent in hemorrhagic stroke patients. The odds that a person with HHcy and folate deficiency has hemorrhagic stroke was found to be significantly high.

CONCLUSION

In our study, high Hcy and low folate levels emerged as risk factors for hemorrhagic stroke.

摘要

背景

中风是全球主要的健康并发症。识别和管理与中风相关的风险因素有助于早期检测、预防和改善患者护理。

目的

调查中风患者高同型半胱氨酸血症（HHcy）以及维生素B6、B12和叶酸缺乏的患病率，并评估与缺血性和出血性中风相关的其他风险因素。

方法

记录研究中所有受试者的详细病史，包括高血压、贫血、空腹血糖、颈动脉厚度、吸烟、饮酒和饮食摄入情况。进行同型半胱氨酸（Hcy）、维生素B6、B12和叶酸测定的标准检测。还进行了血脂和肾功能检查。评估缺血性和出血性中风患者中HHcy、维生素B6、B12和叶酸缺乏以及其他风险因素的患病率和比值比。采用学生t检验和卡方检验对数据进行统计学验证。

结果

在缺血性病例中未观察到HHcy以及维生素B6、B12和叶酸缺乏的情况。发现HHcy和叶酸缺乏在出血性中风患者中较为普遍。发现HHcy和叶酸缺乏的人患出血性中风的比值比显著较高。

结论

在我们的研究中，高Hcy水平和低叶酸水平成为出血性中风的风险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e33f/10259151/363a5479e620/10.1177_09727531221124425-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e33f/10259151/363a5479e620/10.1177_09727531221124425-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e33f/10259151/363a5479e620/10.1177_09727531221124425-fig1.jpg

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