Niazi Farheen, Aslam Ayesha, Khattak Sadaf, Waheed Satia
Neurology, Pakistan Atomic Energy Commission Hospital, Islamabad, PAK.
Neurology, Mayo Hospital, Islamabad, PAK.
Cureus. 2019 Sep 11;11(9):e5625. doi: 10.7759/cureus.5625.
Objective To find out the frequency of hyperhomocysteinemia in young ischaemic stroke patients and its relationship with early morbidity and mortality. Methods This prospective study was conducted on young ischemic stroke patients in Pakistan Atomic Energy Commission General Hospital, Islamabad. Ischaemic stroke patients of age < 45 years were selected from both the outpatient and inpatient departments. A fasting venous blood sample was sent for analysis. Data was collected through a structured proforma and were analyzed using SPSS 24.0 (IBM Corp, Armonk, NY, US). The outcome was measured at discharge using the modified Rankin scale. Results The mean age of the 71 patients in the study was 35.8 years. Overall, 36 (50.7%) cases had hyper-homocysteinemia. The frequency was significantly higher in males and in the age group 36-45 years (63.4%). Levels of homocysteine did not significantly affect the outcome at discharge. Conclusion Hyperhomocysteinaemia, a modifiable risk factor for ischaemic stroke, was seen in about half of young stroke patients. The levels of homocysteine did not correlate with early stroke outcome.
目的 了解青年缺血性卒中患者高同型半胱氨酸血症的发生率及其与早期发病和死亡率的关系。方法 本前瞻性研究在伊斯兰堡巴基斯坦原子能委员会综合医院的青年缺血性卒中患者中进行。从门诊和住院部选取年龄＜45岁的缺血性卒中患者。采集空腹静脉血样进行分析。通过结构化表格收集数据，并使用SPSS 24.0（美国纽约州阿蒙克市IBM公司）进行分析。出院时使用改良Rankin量表测量结局。结果 研究中的71例患者平均年龄为35.8岁。总体而言，36例（50.7%）病例患有高同型半胱氨酸血症。男性和36 - 45岁年龄组的发生率显著更高（63.4%）。同型半胱氨酸水平对出院时的结局无显著影响。结论 高同型半胱氨酸血症是缺血性卒中的一个可改变的危险因素，约半数青年卒中患者存在该情况。同型半胱氨酸水平与早期卒中结局无关。
