Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Petaling Jaya, Selangor, Malaysia.
J Cosmet Dermatol. 2023 Oct;22(10):2810-2815. doi: 10.1111/jocd.15794. Epub 2023 Jun 14.
Application of natural resources from the marine environment in the cosmeceutical industry is gaining great attention.
This study pursues to discover the cosmeceutical potential of two Malaysian algae, Sargassum sp. and Kappaphycus sp. by determining their antioxidant capacity and assessing the presence of their secondary metabolites with cosmeceutical potential using non-targeted metabolite profiling.
Metabolite profiling using Quadrupole Time-of-Flight (Q-TOF) liquid chromatography-mass spectrometry (LC-MS) in the Electrospray Ionization (ESI) mode resulted in 110 putative metabolites in Sargassum sp. and 47 putative metabolites in Kappaphycus sp. and were grouped according to their functions. To the best of our knowledge, the bioactive compounds of both algae have not been studied in any great detail. This is the first report to explore their cosmeceutical potential.
Six antioxidants were detected in Sargassum sp., including fucoxanthin, (3S, 4R, 3'R)-4-Hydroxyalloxanthin, enzacamene N-stearoyl valine, 2-hydroxy-hexadecanoic acid, and metalloporphyrins. Meanwhile, three antioxidants detected in Kappahycus sp., namely Tanacetol A, 2-fluoro palmitic acid and idebenone metabolites. Three antioxidants are found in both algae species, namely, 3-tert-Butyl-5-methylcatechol, (-)-isoamijiol, and (6S)-dehydrovomifoliol. Anti-inflammatory metabolites such as 5(R)-HETE, protoverine, phytosphingosine, 4,5-Leukotriene-A4, and 5Z-octadecenoic acid were also found in both species. Sargassum sp. possesses higher antioxidant capacity as compared to Kappahycus sp. which may be linked to its number of antioxidant compounds found through LC-MS.
Hence, our results conclude that Malaysian Sargassum sp. and Kappaphycus sp. are potential natural cosmeceutical ingredients as we aim to produce algae cosmeceutical products using native algae.
从海洋环境中应用自然资源在化妆品行业中受到了极大的关注。
本研究旨在通过测定两种马来西亚海藻——马尾藻和麒麟菜的抗氧化能力，并利用非靶向代谢物分析评估具有化妆品潜力的次生代谢物的存在，来发现它们在化妆品方面的潜力。
采用电喷雾（ESI）模式的四极杆飞行时间（Q-TOF）液相色谱-质谱（LC-MS）进行代谢物分析，在马尾藻中得到 110 种假定代谢物，在麒麟菜中得到 47 种假定代谢物，并根据其功能进行分组。据我们所知，这两种海藻的生物活性化合物尚未进行过详细研究。这是首次探索它们在化妆品方面的潜力的报告。
在马尾藻中检测到 6 种抗氧化剂，包括岩藻黄质、（3S，4R，3'R）-4-羟基黄烷酮、烯丙酰胺 N-硬脂酰缬氨酸、2-羟基十六烷酸和金属卟啉。同时，在麒麟菜中检测到 3 种抗氧化剂，分别为 Tanacetol A、2-氟棕榈酸和艾地苯醌代谢物。在这两个藻类物种中都发现了 3 种抗氧化剂，分别是 3-叔丁基-5-甲基儿茶酚、（-）-异阿米醇和（6S）-去氢沃氏豆醇。还在这两个物种中发现了抗炎代谢物，如 5(R)-HETE、原荷叶碱、神经酰胺、4,5-白三烯-A4 和 5Z-十八碳烯酸。与麒麟菜相比，马尾藻具有更高的抗氧化能力，这可能与其通过 LC-MS 发现的抗氧化化合物数量有关。
因此，我们的研究结果表明，马来西亚的马尾藻和麒麟菜是有潜力的天然化妆品成分，因为我们旨在使用本土海藻生产海藻化妆品。
