Wuhan Pulmonary Hospital, Wuhan Institute for Tuberculosis Control, Wuhan, 430030, Hubei, China.
Sci Rep. 2023 Jun 14;13(1):9658. doi: 10.1038/s41598-023-36420-w.
To explore the influence of CT findings on the optimal timing of open decorticationin patients with stage III tuberculous empyema. A total of 80 patients with stage III tuberculous empyema who had undergone open decortications were recruited; 44 patients had chest CT findings indicating low-density lines, while 36 patients did not show this imaging finding. Demographic data, perioperative data and preoperative and postoperative chest CT images were collected. In the low-density line group, the duration of disease (P = 0.0030) and the preoperative anti-tuberculosis time (P = 0.0016) were longer than those of the group without low-density lines, and the ESR (P = 0.0218), CRP (P = 0.0027) and leukocyte count (P = 0.0339) were lower in the low-density line group. Additionally, in the median operative time (P = 0.0003), intraoperative blood loss (P < 0.0001), volume of catheter drainage during 48 h after operation (P = 0.0067), chest tube duration (P < 0.0001), and length of hospital stay (P = 0.0154) were significantly lower in the low-density line group than in the group without low-density lines. A total of 88.64% of participants in the low-density line group showed hyperplasia with hyaline degeneration in pathological examination, which was observed only in 41.67% of patients without low-density lines. In addition, gaseous necrosis was considerably higher in patients without a low-density line (P = 0.004), while the low-density line group had a higher rate of treatment success (P < 0.05). Patients with stage III tuberculous empyema presenting with low-density lines around the thickened fibrous pleural rind on preoperative CT imaging may be good candidates for open decortication.
探讨 CT 表现对结核性脓胸Ⅲ期患者行开胸廓清术最佳时机的影响。共纳入 80 例行开胸廓清术的结核性脓胸Ⅲ期患者,其中 44 例 CT 表现为低密度线,36 例无此影像学表现。收集患者的人口统计学资料、围手术期资料及术前和术后胸部 CT 图像。在低密度线组中,疾病持续时间(P=0.0030)和术前抗结核时间(P=0.0016)长于无低密度线组,且 ESR(P=0.0218)、CRP(P=0.0027)和白细胞计数(P=0.0339)低于无低密度线组。此外,在手术时间中位数(P=0.0003)、术中出血量(P<0.0001)、术后 48 小时引流管引流量(P=0.0067)、胸腔引流管留置时间(P<0.0001)和住院时间(P=0.0154)方面,低密度线组明显低于无低密度线组。低密度线组病理检查显示增生伴透明变性者 88.64%,无低密度线组仅 41.67%。此外,无低密度线组的气体性坏死发生率明显较高(P=0.004),而低密度线组的治疗成功率较高(P<0.05)。术前 CT 影像学显示增厚的纤维性胸膜壁有低密度线的结核性脓胸Ⅲ期患者可能是行开胸廓清术的良好候选者。