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对 CT 影像显示存在低密度线的 III 期结核脓胸患者行开胸廓清术。

Open decortication for patients presenting with stage III tuberculous empyema with low density lines on CT imaging.

机构信息

Wuhan Pulmonary Hospital, Wuhan Institute for Tuberculosis Control, Wuhan, 430030, Hubei, China.

出版信息

Sci Rep. 2023 Jun 14;13(1):9658. doi: 10.1038/s41598-023-36420-w.

Abstract

To explore the influence of CT findings on the optimal timing of open decorticationin patients with stage III tuberculous empyema. A total of 80 patients with stage III tuberculous empyema who had undergone open decortications were recruited; 44 patients had chest CT findings indicating low-density lines, while 36 patients did not show this imaging finding. Demographic data, perioperative data and preoperative and postoperative chest CT images were collected. In the low-density line group, the duration of disease (P = 0.0030) and the preoperative anti-tuberculosis time (P = 0.0016) were longer than those of the group without low-density lines, and the ESR (P = 0.0218), CRP (P = 0.0027) and leukocyte count (P = 0.0339) were lower in the low-density line group. Additionally, in the median operative time (P = 0.0003), intraoperative blood loss (P < 0.0001), volume of catheter drainage during 48 h after operation (P = 0.0067), chest tube duration (P < 0.0001), and length of hospital stay (P = 0.0154) were significantly lower in the low-density line group than in the group without low-density lines. A total of 88.64% of participants in the low-density line group showed hyperplasia with hyaline degeneration in pathological examination, which was observed only in 41.67% of patients without low-density lines. In addition, gaseous necrosis was considerably higher in patients without a low-density line (P = 0.004), while the low-density line group had a higher rate of treatment success (P < 0.05). Patients with stage III tuberculous empyema presenting with low-density lines around the thickened fibrous pleural rind on preoperative CT imaging may be good candidates for open decortication.

摘要

探讨 CT 表现对结核性脓胸Ⅲ期患者行开胸廓清术最佳时机的影响。共纳入 80 例行开胸廓清术的结核性脓胸Ⅲ期患者,其中 44 例 CT 表现为低密度线,36 例无此影像学表现。收集患者的人口统计学资料、围手术期资料及术前和术后胸部 CT 图像。在低密度线组中,疾病持续时间(P=0.0030)和术前抗结核时间(P=0.0016)长于无低密度线组,且 ESR(P=0.0218)、CRP(P=0.0027)和白细胞计数(P=0.0339)低于无低密度线组。此外,在手术时间中位数(P=0.0003)、术中出血量(P<0.0001)、术后 48 小时引流管引流量(P=0.0067)、胸腔引流管留置时间(P<0.0001)和住院时间(P=0.0154)方面,低密度线组明显低于无低密度线组。低密度线组病理检查显示增生伴透明变性者 88.64%,无低密度线组仅 41.67%。此外,无低密度线组的气体性坏死发生率明显较高(P=0.004),而低密度线组的治疗成功率较高(P<0.05)。术前 CT 影像学显示增厚的纤维性胸膜壁有低密度线的结核性脓胸Ⅲ期患者可能是行开胸廓清术的良好候选者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3827/10267101/cbc4bb1866b2/41598_2023_36420_Fig1_HTML.jpg

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