Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.
Cardiovascular Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Sci Rep. 2023 Jun 14;13(1):9652. doi: 10.1038/s41598-023-36135-y.
Insulin resistance (IR) is associated with cardiovascular disease in non-diabetic patients. The triglyceride-glucose (TyG) index, incorporating serum glucose and insulin concentrations, is a surrogate insulin resistance marker. We investigated its association with obstructive coronary artery disease (CAD) and sex differences therein. Patients with stable angina pectoris requiring invasive coronary angiography between January 2010 and December 2018 were enrolled. They were divided into two groups according to TyG index. Two interventional cardiologists diagnosed obstructive CAD by angiography review. Demographic characteristics and clinical outcomes were compared between groups. Relative to lower index, patients with higher (≥ 8.60) TyG index had higher BMIs and more prevalent hypertension, diabetes, and elevated lipid profiles [total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), fasting plasma glucose (FPG)]. Higher TyG index increased women's obstructive CAD risk after multivariate adjustment (adjusted odds ratio (aOR) 2.15, 95% confidence interval (95% CI) 1.08-4.26, p = 0.02) in non-diabetic populations compared with men. No sex difference was found for diabetic patients. Higher TyG index significantly increased the obstructive CAD risk, overall and for non-diabetic women. Larger-scale studies are needed to confirm our findings.
胰岛素抵抗（IR）与非糖尿病患者的心血管疾病有关。甘油三酯-葡萄糖（TyG）指数，结合了血清葡萄糖和胰岛素浓度，是一种替代的胰岛素抵抗标志物。我们研究了它与阻塞性冠状动脉疾病（CAD）的关系及其性别差异。2010 年 1 月至 2018 年 12 月期间，因稳定型心绞痛需要进行有创冠状动脉造影的患者被纳入研究。根据 TyG 指数将他们分为两组。两名介入心脏病学家通过血管造影复查诊断阻塞性 CAD。比较了两组之间的人口统计学特征和临床结局。与较低的指数相比，TyG 指数较高（≥8.60）的患者 BMI 更高，高血压、糖尿病和血脂异常更为常见[总胆固醇、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、甘油三酯（TG）、空腹血糖（FPG）]。在非糖尿病患者中，经多变量调整后，较高的 TyG 指数增加了女性发生阻塞性 CAD 的风险（调整后的优势比（aOR）为 2.15，95%置信区间（95%CI）为 1.08-4.26，p=0.02），而在男性中则没有发现性别差异。对于糖尿病患者，没有发现性别差异。较高的 TyG 指数显著增加了阻塞性 CAD 的风险，无论是整体人群还是非糖尿病女性。需要更大规模的研究来证实我们的发现。
