Sant'Anna Thaís B, Araujo Natalia M
Laboratory of Molecular Virology and Parasitology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro 21041-250, RJ, Brazil.
Microorganisms. 2023 Apr 22;11(5):1101. doi: 10.3390/microorganisms11051101.
The hepatitis B virus (HBV) genotype D (HBV/D) is the most extensively distributed genotype worldwide with distinct molecular and epidemiological features. This report provides an up-to-date review on the history of HBV/D subgenotyping and misclassifications, along with large-scale analysis of over 1000 HBV/D complete genome sequences, with the aim of gaining a thorough understanding of the global prevalence and geographic distribution of HBV/D subgenotypes. We have additionally explored recent paleogenomic findings, which facilitated the detection of HBV/D genomes dating back to the late Iron Age and provided new perspectives on the origins of modern HBV/D strains. Finally, reports on distinct disease outcomes and responses to antiviral therapy among HBV/D subgenotypes are discussed, further highlighting the complexity of this genotype and the importance of HBV subgenotyping in the management and treatment of hepatitis B.
乙型肝炎病毒（HBV）D基因型（HBV/D）是全球分布最广泛的基因型，具有独特的分子和流行病学特征。本报告提供了关于HBV/D亚基因分型历史和错误分类的最新综述，以及对1000多个HBV/D完整基因组序列的大规模分析，目的是全面了解HBV/D亚基因型的全球流行情况和地理分布。我们还探讨了最近的古基因组学发现，这些发现有助于检测可追溯到铁器时代晚期的HBV/D基因组，并为现代HBV/D毒株的起源提供了新的视角。最后，讨论了关于HBV/D亚基因型之间不同疾病结局和对抗病毒治疗反应的报告，进一步凸显了该基因型的复杂性以及HBV亚基因分型在乙型肝炎管理和治疗中的重要性。
