Brophy C M, Moore J G, Christian P E, Egger M J, Taylor A T
Dig Dis Sci. 1986 Aug;31(8):799-806. doi: 10.1007/BF01296046.
Radiolabeled liquid and solid portions of standardized 300-g meals were administered on four different study days to eight healthy subjects in an attempt to define the range of inter- and intrasubject variability in gastric emptying. Meal half emptying times, analysis of variance, and intraclass correlations were computed and compared within and between subjects. The mean solid half emptying time was 58 +/- 17 min (range 29-92), while the mean liquid half emptying time was 24 +/- 8 min (range 12-37). A nested random effects analysis of variance showed moderate intrasubject variability for solid emptying and high intrasubject variability for liquid emptying. The variability of solid and liquid emptying was comparable and relatively large when compared with other reports in the literature. The isotopic method for measuring gastric emptying is a valuable tool for investigating problems in gastric pathophysiology, particularly when differences between groups of subjects are sought. However, meal emptying time is a variable phenomenon in healthy subjects with significant inter- and intraindividual day-to-day differences. These day-to-day variations in gastric emptying must be considered in interpreting individual study results.
在四个不同的研究日，给八名健康受试者给予标准化300克餐食的放射性标记液体和固体部分，以试图确定胃排空过程中受试者间和受试者内变异性的范围。计算并比较了受试者内和受试者间的餐食半排空时间、方差分析和组内相关系数。固体平均半排空时间为58±17分钟（范围29 - 92分钟），而液体平均半排空时间为24±8分钟（范围12 - 37分钟）。方差的嵌套随机效应分析显示，固体排空的受试者内变异性中等，液体排空的受试者内变异性高。与文献中的其他报告相比，固体和液体排空的变异性相当且相对较大。测量胃排空的同位素方法是研究胃病理生理学问题的一种有价值工具，特别是在寻找受试者组间差异时。然而，餐食排空时间在健康受试者中是一种可变现象，个体间和个体内每天都有显著差异。在解释个体研究结果时，必须考虑胃排空的这些每日变化。
